The Louisville Cardinals (1-1) battle the Pittsburgh Panthers (2-0) at Heinz Field in Pittsburgh, Penn., for a 12:00 p.m. ET kickoff Saturday. We analyze the Louisville-Pittsburgh college football betting odds and lines, with picks and best bets.
Louisville at Pittsburgh: Betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 1:10 p.m. ET.
- Money line: Pittsburgh -134 (bet $134 to win $100) | Louisville +110 (bet $100 to win $110)
- Against the spread/ATS: Pittsburgh -2.5, -110 (bet $110 to win $100) | Louisville +2.5, -110 (bet $110 to win $100)
- Over/Under: 54.5, Over -110 (bet $110 to win $100) | Under -110 (bet $110 to win $100)
Louisville at Pittsburgh: Three things to know
- The Cardinals offense has been on fire, ranking 13th in the nation with 501.5 total yards and they’re eighth in the country with 325.0 passing yards per contest, as QB Micale Cunningham has registered 650 passing yards, six touchdowns and two interceptions, and one rushing score, too.
- The Panthers rush defense ranks No. 1 in the nation, allowing 26.0 rushing yards per game through two outings while checking in third with just 154.0 total yards per game allowed. Louisville will certainly put a dent in those numbers, as they’re not Austin Peay or Syracuse.
- Louisville WR Tutu Atwell has rolled up 192 receiving yards and two touchdowns, and RB Javian Hawkins has run for 235 yards and two scores, as the Cards have had a balanced offense. They just haven’t stopped anyone, coughing up 366.5 total yards and 34.0 points per game.
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Louisville at Pittsburgh: Odds, betting lines and picks
Prediction
Louisville 31, Pittsburgh 26
Money line (ML)
LOUISVILLE (+110) is a solid value on the road as short ‘dogs, as their offense will be able to move the ball like Pittsburgh (-134) hasn’t seen so far this season. It won’t be a slam-dunk victory, as the lack of solid defense from the Cards will keep the Panthers in the game. But they don’t have nearly the high-octane offense to help Pittsburgh across the finish line.
Against the spread (ATS)
LOUISVILLE (+2.5, -110) is catching a deuce and a half, but playing them straight up is a better option and will earn you more money.
Over/Under (O/U)
The OVER 54.5 (-110) is worth playing lightly, as mentioned above, Louisville has really struggled defensively. Pitt’s defense has looked good, but they faced an FCS team and a winless and stumbling Syracuse side. The Cardinals are a whole other animal.
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