The Louisville Cardinals (1-3 overall, 0-3 ACC) and Notre Dame Fighting Irish (3-0, 2-0) meet at Notre Dame Stadium in South Bend, Ind., for a 2:30 p.m. ET kickoff Saturday (on NBC). Below, we analyze the Louisville-Notre Dame college football betting odds and lines, with picks and best bets.
The Fighting Irish are the No. 4 team in the Amway Coaches Poll powered by USA TODAY Sports.
Louisville at Notre Dame: Betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 7:14 a.m. ET.
- Money line: Louisville +475 (bet $100 to win $475) | Notre Dame -667 (bet $667 to win $100)
- Against the spread/ATS: Louisville +17.5, -121 (bet $121 to win $100) | Notre Dame -17.5, +100 (bet $100 to win $100)
- Over/Under: 63.5 (O: -115 | U: -106)
Louisville at Notre Dame: Three things to know
- The Cardinals are just one of three ACC teams yet to win a conference game this season, and they’re tied with Florida State in the basement of the standings at 0-3 inside the league. It’s mostly due to a poor defensive effort, allowing 34.3 PPG to rank 62nd in the country.
- Louisville QB Malik Cunningham has thrown for 986 yards through four games, including two 300-yard outings, and he has nine TD passes overall. He and WR Tutu Atwell are one of the most lethal pass-catch duos in the ACC.
- The Fighting Irish defense has allowed just 323.3 total yards (15th), 111.3 rushing yards (21st) and 13.0 points allowed (8th) per game.
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Louisville at Notre Dame: Odds, betting lines and picks
Prediction
Notre Dame 40, Louisville 21
Money line (ML)
Notre Dame (-667) will cost you nearly seven times your potential return with a straight-up victory. The Irish are not losing, but why risk that much for such a minuscule profit? AVOID.
Against the spread (ATS)
NOTRE DAME -17.5 (+100) has covered just once in three games, but it has been favored north of 21 in each of those outings. Louisville has managed an 0-2-1 ATS mark across the past three after covering its only game of the season against Western Kentucky in the opener. The Cards defense cannot be trusted, and you expect the Irish to pull away in the second half.
Over/Under (O/U)
UNDER 63.5 (-106) is the play, even if Louisville has hit the Over in three of its four outings overall. The Cards have a minus-5 turnover ratio, and that’s a little worrisome, as points could be going back the other way. But in the end, the Under should hang on. Go lightly here.
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