Buffalo Bills favored at home over Los Angeles Chargers in Week 12

The Buffalo Bills are the betting favorites by the odds and lines for their Week 12 home game against the Los Angeles Chargers.

The Los Angeles Chargers (3-7) visit the Buffalo Bills (7-3) Sunday of Week 12. Kickoff will be at 1 p.m. ET at Bills Stadium. Below, we take a look at the early Week 12 Chargers-Bills betting odds and lines at BetMGM Sportsbook.

The Chargers defeated the New York Jets 34-28 Sunday, snapping a three-game losing skid in the process. QB Justin Herbert went 37-for-49 for 366 yards, throwing 3 touchdown passes witht no interceptions. WR Keenan Allen had a monster game for Los Angeles, hauling in 16 catches for 145 yards (both season highs). The Chargers will be looking to put an end to a four-game losing streak away from home.

The Bills saw a three-game win streak come to an in Phoenix in Week 10 before their Week 11 bye. Buffalo was dealt a 32-30 loss by the Arizona Cardinals. The Bills led that game, 23-9, midway through the third quarter. Buffalo rushed for just 73 yards at Arizona and has tallied all of 107 yards over its last two games. The Bills are 4-1 at home this season

Chargers at Bills betting odds, spread and line

Odds via BetMGM; last updated Tuesday at 8:45 a.m. ET. 

  • Money line: Chargers +210 (bet $100 to win $210) / Bills -250 (bet $250 to win $100) | Bet now
  • Against the spread: Chargers +6, -110 (bet $110 to win $100) / Bills -6, -110 (bet $110 to win $100) | Bet now
  • Total: 54.5, Over -110 (bet $110 to win $100) / Under -110 (bet $110 to win $100) | Bet now

New to NFL betting?

The Chargers, at +210 odds, have an implied 32.26% chance of winning, or 21/10 fractional odds. If Los Angeles wins outright or loses by fewer than 6 points, a Chargers +6 (-110) against the spread bet wins. A Bills win by 6 spells a push.

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At -250 odds, the Bills have an implied win probability of 71.43% (2/5 fractional, 1.40 decimal). Buffalo must win by 7 or more points for a Bills -6 (-110) ATS ticket to cash.

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