Detroit Lions at Jacksonville Jaguars odds, picks and best bets

Previewing the Detroit Lions at Jacksonville Jaguars Week 6 betting odds and lines, with NFL betting picks, tips and best bets.

The Jacksonville Jaguars (1-4) host the Detroit Lions (1-3) at TIAA Bank Field Sunday of Week 6. Kickoff will be at 1 p.m. ET. Below, we preview the Lions-Jaguars Week 6 betting odds and lines and make our NFL picks and best bets.

Lions at Jaguars betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 3:45 p.m. ET.

  • Money line: Lions -176 (bet $176, win $100) | Jaguars +150 (bet $100, win $150)
  • Against the spread/ATS: Lions -3.5 (-106) | Jaguars +3.5 (-115)
  • Over/Under: 54.5 (O: -110, U: -110)

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Lions at Jaguars game notes

  • The Lions are coming off a Week 5 bye which followed a 35-29 loss at the New Orleans Saints in Week 4.
  • The Jaguars have lost four straight games after beating the Indianapolis Colts 27-20 in Week 1. Each of their last three losses was by at least 8 points. Their last three losses were against teams that previously didn’t have a win on the season.
  • Both teams are in the bottom half of the league with under 25 points per game on offense. They’re both in the bottom eight in points allowed per game.
  • Jacksonville is minus-2 in turnover differential with five takeaways and seven giveaways. Detroit is plus-1 with four takeaways and three giveaways.
  • Head coaches Matt Patricia of the Lions and Doug Marrone of the Jaguars are considered to be on the hot seat. Two teams (Houston Texans and Atlanta Falcons) have already dismissed their head coaches this season.
  • The Jaguars are 2-3 against the spread; the Lions are 1-3. Detroit is 3-1 against the Over/Under; Jacksonville is 3-2.

Lions at Jaguars key injuries

Lions

  • TE Hunter Bryant (concussion) IR
  • C.J. Moore (calf) probable
  • RB Adrian Peterson (illness) questionable
  • CB Desmond Trufant (hamstring) questionable

Jaguars

  • LB Dakota Allen (foot) questionable
  • DE Josh Allen (knee) questionable
  • WR DJ Chark Jr. (ankle) questionable
  • TE Tyler Eifert (neck) questionable
  • DT Arby Jones (ankle/hamstring) questionable
  • WR Laviska Shenault Jr. (hamstring) probable

Lions at Jaguars: Odds, betting lines, picks and prediction

Prediction

Lions 27, Jaguars 20

Money line (?)

Take the LIONS (-176) as modest favorites coming off their bye week. They beat a good Arizona Cardinals team 26-23 on the road prior to the loss to the Saints. The Jaguars have regressed to their preseason expectations following the surprising Week 1 upset of the division-rival Colts.

Against the spread (?)

Get better value on the LIONS -3.5 (-106) by backing them to win by at least 4 points. As noted above, the Jags have lost three straight games by at least 8 points, with two of those decided by more than 10 points.

Over/Under (?)

Take the UNDER 54.5 (-110) with a high degree of confidence. Defenses are beginning to catch up to offenses after an initial surge of scoring around the league to open the season. Both coaches are also fighting for their jobs, so the defenses should be clamping down.

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