The Detroit Lions (0-2) try to get their first win of the season and will take on the Arizona Cardinals (2-0) at State Farm Stadium Sunday afternoon at 4:25 p.m. ET in Glendale, Arizona. Below, we preview the Lions-Cardinals betting odds and lines and make our NFL picks and best bets.
Lions at Cardinals betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday 4:15 p.m. ET.
- Money line: Lions +215 (bet $100, win $215) | Cardinals -250 (Bet $250, win $100)
- Against the spread/ATS: Lions +5.5 (-110) | Cardinals -5.5 (-110)
- Over/Under: 55.5 (O: -110, U: -110)
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Lions at Cardinals game notes
- The Lions have allowed 46 second-half points in two games.
- Detroit is giving up an average of 34.5 points per game, the third-highest total in the league.
- Cardinals QB Kyler Murray is the first player in the Super Bowl era to have more than 500 passing yards and more than 150 rushing yards through two games of a season.
- The Cardinals are averaging 170 rushing yards per game.
Lions at Cardinals key injuries
Lions
- WR Kenny Golladay (hamstring) questionable/limited in practice Friday
- RT Halapoulivaati Vaitai (foot) questionable/limited in practice Friday
- CB Desmond Trufant (hamstring) doubtful/limited in practice Friday
Cardinals
- WR Christian Kirk (groin) out
- C Mason Cole (hamstring) out
- DE Jordan Phillips (ankle) questionable/limited in practice Friday
- CB Dre Kirkpatrick (neck) questionable/limited in practice Friday
Lions at Cardinals: Odds, betting lines, picks and prediction
Prediction
Cardinals 34, Lions 20
Money line (?)
The Cardinals look good so far and have produced over 400 yards and averaged 27 points through two games against two very talented defenses. Detroit’s defense is not that good. This has the makings of a blowout. Take the CARDINALS (-250). New to sports betting? A $250 bet on the Cardinals (-250) fetches a profit of $100 if Arizona beats Detroit outright.
Against the Spread (?)
The Cardinals are a perfect 2-0 ATS this season. They covered when favored and as underdogs. The Lions have failed to cover either one of their losses. Take the CARDINALS -5.5 (-110). New to sports betting? A $110 bet on the Cardinals -5.5 (-110) returns a $100 profit if Arizona wins or loses by five or fewer points.
Over/Under (?)
Arizona’s games have gone Under in each of their first two games because its defense has done its job. Detroit’s games have both gone Over. With the total so high, it will be close but go with the UNDER 55.5 (-110).
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