Cleveland Guardians at Chicago White Sox odds, picks and predictions

Analyzing Thursday’s Cleveland Guardians at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Cleveland Guardians (82-67) and Chicago White Sox (76-73) close out a 3-game AL Central series Wednesday. First pitch from Guaranteed Rate Field is at 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. White Sox odds with MLB picks and predictions.

Season series: Cleveland leads 11-7

Cleveland has taken the first 2 games of this series, and the Guardians are 12-2 in their last 14. Cleveland has scored 18 runs in this series and 29 runs in its last 3 games.

The White Sox have been up and down in the 2nd half.  Chicago was within a game-and-a-half of Cleveland as recently as 12 days ago. But with the Guardians winning the first 2 games of this set, the ChiSox now find themselves 6 games back in the AL Central race and 5 1/2 back in the AL wild-card hunt.

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Guardians at White Sox projected starters

RHP Shane Bieber vs. RHP Johnny Cueto

Bieber (11-8, 2.83 ERA) is tabbed for his 29th start. He has a 1.03 WHIP, 1.7 BB/9 and 9.1 K/9 in 181 1/3 IP.

  • Has a 1.81 ERA over his last 7 starts
  • Owns a 2.67 ERA across his last 5 starts against the White Sox

Cueto (7-8, 3.09 ERA) owns a 1.20 WHIP, 2.0 BB/9 and 5.7 K/9 through 139 2/3 IP across 22 games (21 starts).

  • Pitched 8 2/3 shutout innings against Cleveland Aug. 20
  • Owns a 6.00 ERA, 1.43 WHIP across his last 4 starts

Guardians at White Sox odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:33 p.m. ET.

  • Money line: Guardians -145 (bet $145 to win $100) | White Sox +120 (bet $100 to win $120)
  • Run line (RL)/Against the spread (ATS): Guardians -1.5 (+120) | White Sox +1.5 (-145)
  • Over/Under (O/U): 7.5 (O: +110 | U: -135)

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Guardians at White Sox picks and predictions

Prediction

Guardians 4, White Sox 3

Money line

Bieber has been ultra sharp of late. Cueto has been running into too many bats over recent turns. His overall quality-of-contact numbers may not even support an ERA under 4.00, let alone one near 3.00.

Cleveland has the better bullpen, and over the last several weeks its been a pen getting a slew of ground balls while holding hard contact in check.

TAKE CLEVELAND (-145). Make it a partial-unit play unless a price of -140 or better avails itself.

Run line/Against the spread

PASS. Both games have played a lot of close games recently.

Over/Under

Mixed signals here: Cool night, wind out. Bieber on a roll, Cueto likely too far over his skis. The Under 7.5 is a slight lean but an overly expensive proposition.

PASS.

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Cleveland Guardians at Chicago White Sox odds, picks and predictions

Analyzing Wednesday’s Cleveland Guardians at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Cleveland Guardians (81-67) and Chicago White Sox (76-72) continue a 3-game AL Central series Wednesday. First pitch from Guaranteed Rate Field is at 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. White Sox odds with MLB picks and predictions.

Season series: Cleveland leads 10-7

Cleveland took Tuesday’s series opener 10-7 in 11 innings. The Guardians are 11-2 in their last 13 games and have logged a .789 OPS over that stretch.

The White Sox have been up and down in the 2nd half, but are 13-6 since Aug. 31. Chicago has gone into extra innings in 3 of its last 4 games.

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Guardians at White Sox projected starters

RHP Triston McKenzie vs. RHP Lance Lynn

McKenzie (10-11, 3.08 ERA) has appeared in 28 games, making 27 starts. He has a 0.97 WHIP, 2.3 BB/9 and 8.7 K/9 in 172 1/3 IP.

  • Owns a 2.84 ERA across his last 7 starts
  • That 7-start span includes an Aug. 14 outing against the White Sox in which he struck out 14 batters
  • Current Chicago bats own an aggregate .655 OPS

Lynn (7-5, 3.99 ERA) has a 1.07 WHIP, 1.4 BB/9 and 9.8 K/9 through 103 2/3 IP in 18 starts.

  • Facing the Guardians for a 2nd straight start and for a 3rd time in the last 5 weeks; has a 5.46 ERA in his last 5 starts against Cleveland (2021-22).
  • Has logged a 1.89 ERA over his last 3 home starts
  • Makes this start on 5 days’ rest, which has been a preferred rest interval in recent years (.652 OPS allowed in 2022)

Guardians at White Sox odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:36 a.m. ET.

  • Money line: Guardians +120 (bet $100 to win $120) | White Sox -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians +1.5 (-180) | White Sox -1.5 (+145)
  • Over/Under (O/U): 7.5 (O: -115 | U: -107)

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Guardians at White Sox picks and predictions

Prediction

White Sox 5, Guardians 4

Money line

The White Sox are a lean here. Both starting pitchers are fly-ballers, but McKenzie is more so and the weather forecast calls for a double-digit wind blowing out and helping the batters.

The recent run differential for the White Sox (plus-42 last 19 games) is compelling, and Chicago has played Cleveland tough.

The ChiSox are 16-11 in their last 27 home games.

TAKE CHICAGO (-145). Make it a partial-unit play unless it eventually gets priced at -140 or better.

Run line/Against the spread

PASS. Both games have played a lot of close games recently.

Over/Under

Both bullpens sport some luck factors of late that would support some regression toward more traffic on the bags and more runs crossing the plate. And both bullpens are the the fatigue zone, especially at the back end.

Add in the outward breeze helping fly balls, and figure a small-to-moderate lean on the OVER 7.5 (-115).

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Cleveland Guardians at Chicago White Sox odds, picks and predictions

Analyzing Tuesday’s Cleveland Guardians at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Cleveland Guardians (80-67) and Chicago White Sox (76-71) open a 3-game AL Central series Tuesday. First pitch from Guaranteed Rate Field is at 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. White Sox odds with MLB picks and predictions.

Season series: Cleveland leads 9-7

The Guardians are coming off a 6-2 homestand that included a Thursday loss to this ChiSox squad. Cleveland went 6-1 in its first 7 games against Chicago but is just 3-6 against the Sox since.

The mercurial White Sox are back at home after a 3-1 road trip. After the all-star break, strong pitching got Chicago within a game of 1st place in the AL Central by Aug. 17.

The Sox then suffered through a 2-10 stretch in late August, however, Chicago has gone 13-5 since Aug. 31. The Pale Hose have outscored foes by 2 1/2 runs per game (5.67 runs per game vs. 3.17 allowed) across that span.

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Guardians at White Sox projected starters

RHP Aaron Civale vs. RHP Dylan Cease

Civale (2-6, 5.40 ERA) is tabbed for his 17th start of the season. He has a 1.31 WHIP, 2.4 BB/9 and 9.0 K/9 through 75 IP.

  • Coming off the 15-day IL (forearm) for this turn; last pitched Aug. 28
  • Owns a 6.43 ERA and 1.41 WHIP on the road

Cease (14-7, 2.16 ERA) makes his 30th start. He has a 1.08 WHIP, 3.7 BB/9 and 11.5 K/9 through 167 IP.

  • Sports the AL’s 3rd-best ERA
  • Has benefited from a .263 batting average on balls in play

Guardians at White Sox odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:43 a.m. ET.

  • Money line: Guardians +140 (bet $100 to win $140) | White Sox -175 (bet $175 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians +1.5 (-155) | White Sox -1.5 (+125)
  • Over/Under (O/U): 7.5 (O: +105 | U: -130)

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Guardians at White Sox picks and predictions

Prediction

White Sox 6, Guardians 3

Money line

PASS. Look to the Run Line for the better play in this series opener.

Run line/Against the spread

The recent run differential for the White Sox is compelling, and Chicago has played Cleveland tough.

The Pale Hose opened the 2nd half with back-to-back home losses against this Cleveland club. Beginning with wins over the Guardians the next 2 days, Chicago is 16-10 over its last 26 games at home.

TAKE CHICAGO -1.5 (+125). Tag this play as a partial-unit one.

Over/Under

There is some gray area presented by Civale returning from injury (after an ineffective rehab outing in the minors). Cease has gotten by with a .162 BABIP over his last 5 starts. And both bullpens sport some luck factors of late that would support some regression toward more traffic on the bags and more runs crossing the plate.

However, both offenses profile as being slightly overcooked, so it’s not wise to lean too heavily into an Over when they are on the same diamond. So, consider a partial-unit play on the OVER 7.5 (+105).

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Cleveland Guardians at Chicago White Sox odds, picks and predictions

Analyzing Tuesday’s Cleveland Guardians at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Cleveland Guardians (15-14) and Chicago White Sox (14-14) meet Tuesday for the middle game of a 3-game set at Guaranteed Rate Field. First pitch is set for 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. White Sox odds with MLB picks and predictions.

Season series: Cleveland leads 4-0 and has outscored Chicago 31-14.

The Guardians took Monday’s opener 12-9 in extra-innings and are 8-2 over their last 10 games. The 12 runs Monday are part of a trend with this club away from home: the Guardians’ road OPS of .752 ranks 3rd in MLB.

The Pale Hose went into this series on a 6-game win streak. However, Chicago yielded more runs Monday than it had over those 6 straight wins.

Guardians at White Sox projected starters

RHP Cal Quantrill vs. RHP Lucas Giolito

Quantrill (1-1, 3.54 ERA) makes his 6th start. He has a 1.21 WHIP, 4.8 BB/9 and 5.5 K/9 through 28 IP.

  • Has not allowed more than 3 earned runs in any start.
  • Had a 1.10 ERA through 16 1/3 IP across 2 starts and 4 relief appearances against the White Sox in 2021.

Giolito (1-1, 3.20 ERA) makes his 5th start. He has a 1.17 WHIP, 3.7 BB/9 and 14.6 K/9 through 19 2/3 IP.

  • Fanned 10 in 5 2/3 IP in his last start Wednesday at the Chicago Cubs but also allowed 2 home runs and 3 runs overall.
  • Has allowed 6 earned runs in his last 11 2/3 IP.
  • Current Cleveland bats own a .517 OPS against him.

Guardians at White Sox odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 10:38 a.m. ET.

  • Money line: Guardians +155 (bet $100 to win $155) | White Sox -190 (bet $190 to win $100)
  • Run line (RL): Guardians +1.5 (-140) | White Sox -1.5 (+115)
  • Over/Under (O/U): 7.5 (O: -125 | U: +100)

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Guardians at White Sox picks and predictions

Prediction

White Sox 6, Guardians 3

Money line

Quantrill’s velocity is down a couple of ticks and a beneficial .222 batting average on balls in play has tamped down his ERA. Giolito, meanwhile, has pitched around the traffic of a .314 BABIP. In the year of the dying-short-of-the-wall fly ball, he’s also been hurt by a 22.2% home run rate on flies.

The Chicago ‘pen is better rested in the right slots heading into this game.

KEEP AN EYE ON THE WHITE SOX (-190). A drop in price to -185 or better makes Chicago a solid play.

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Run line/Against the spread

TAKE CHICAGO -1.5 (+115).

A lot rides on Quantrill in this one — too much. The tag on getting the ChiSox by with the 2-run cushion is fair.

Over/Under

The Over was a solid play Monday and is the general lean for the series. A warmed-up night in Chicago — with temps in the 80s — gets mixed with some fade-Quantrill and fade-both bullpens leans.

BACK THE OVER 7.5 (-125).

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Cleveland Guardians at Chicago White Sox odds, picks and predictions

Analyzing Monday’s Cleveland Guardians at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Cleveland Guardians (14-14) and Chicago White Sox (14-13) clash Monday for an 8:10 p.m. ET first pitch to open a 3-game series at Guaranteed Rate Field. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. White Sox odds with MLB picks and predictions.

Season series: Cleveland leads 3-0 and has outscored Chicago 19-5.

The Guardians are coming off taking 3 of 4 games against the Toronto Blue Jays and are 7-2 over their last 9 outings. Cleveland’s road OPS of .748 ranks second in MLB.

The Pale Hose are coming off back-to-back series sweeps, and they tote a 6-game win streak into this set against Cleveland.

Guardians at White Sox projected starters

RHP Zach Plesac vs. RHP Michael Kopech

Plesac (1-3, 4.44 ERA) makes his 6th start of the season. He has a 1.41 WHIP, 2.7 BB/9 and 5.5 K/9 through 26 1/3 IP.

  • Has allowed 10 ER in his last 8 2/3 IP.
  • Current White Sox batters own a .779 OPS against him.

Kopech (0-0, 1.17 ERA) owns 1.04 WHIP, 4.3 BB/9 and 9.0 K/9 through 23 IP across 5 starts.

  • Pitched 4 shutout frames at the Chicago Cubs Tuesday in his last outing.

Guardians at White Sox odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 11 a.m. ET.

  • Money line: Guardians +145 (bet $100 to win $145) | White Sox -180 (bet $180 to win $100)
  • Run line (RL): Guardians +1.5 (-145) | White Sox -1.5 (+120)
  • Over/Under (O/U): 7.5 (O: -110 | U: -110)

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Guardians at White Sox picks and predictions

Prediction

White Sox 5, Guardians 4

Money line

Cleveland has batting and pitching/defense support numbers that make for a club playing 2 or 3 games over .500, so its record figures to be a tad underrated. However, the juice here is drowning out any value potential. AVOID.

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Run line/Against the spread

TAKE CLEVELAND +1.5 (-145).

The Guardians own a fine .759 OPS over their 7-2 surge. They’ve played better on the road than their 7-9 mark would indicate.

Over/Under

Peg both offenses as being a bit undervalued, and both bullpens could use a day to reset and they’re not getting one.

BACK THE OVER 7.5 (-110).

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Gannett may earn revenue from Tipico for audience referrals to betting services. Tipico has no influence over nor are any such revenues in any way dependent on or linked to the newsrooms or news coverage. See Tipico.com for Terms and Conditions. 21+ only. Gambling problem? Call 1-800-GAMBLER (NJ), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA).

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