Atlanta Falcons at San Francisco 49ers odds, picks and best bets

Previewing Sunday’s Atlanta Falcons at San Francisco 49ers sports betting odds and lines, with NFL betting picks, tips and best bets.

The Atlanta Falcons (4-9) visit the San Francisco 49ers (11-2) Sunday of Week 15 for a 4:25 p.m. ET kickoff at Levi’s Stadium. We analyze the Falcons-49ers odds and sports betting lines, while providing NFL betting tips and picks for this matchup.

Falcons at 49ers: Week 15 preview, betting trends and notes


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  • The 49ers rank second in the NFL with 30.5 points per game on offense, and they’re third defensively with 17.6 PPG allowed.
  • The Falcons are 14th offensively (23.1 PPG) and 26th defensively (26.4 PPG allowed).
  • San Francisco has a turnover differential of plus-6 to the minus-7 split for Atlanta.
  • The 49ers allow 150.8 passing yards per game. The Falcons rank third in the NFL with 295.7 passing yards per game but average just 80.8 rushing yards.
  • The Falcons have scored on 50% of their fourth-quarter drives since the beginning of last season. Those garbage-time points can inflate the point total.
  • The Falcons are 1-19 when scoring fewer than 22 points since the start of 2016.

Falcons at 49ers: Key injuries

Falcons WR Calvin Ridley (abdomen) and CB Desmond Trufant (arm) will miss the rest of the season after suffering Week 14 injuries.

49ers CB Richard Sherman (hamstring) isn’t expected to play. DL Dee Ford (hamstring) is likely to miss multiple weeks.

Falcons at 49ers: Odds, betting lines and prediction

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 3:35 p.m. ET.

Prediction

49ers 35, Falcons 22

Moneyline (?)

The 49ers are home favorites, and they’ll win, but the -556 odds for the simple outright victory aren’t worth any sort of wager. San Francisco regained the NFC West lead with a 48-46 win over the New Orleans Saints last week and are looking for a first-round bye.

The Falcons trounced the rival Carolina Panthers 40-20 at home last week, but they’re just 2-4 on the road and can’t compete against the Niners’ defense without their No. 2 receiver.

New to sports betting? A $10 wager on the Niners to win outright returns a profit of just $0.18.

Against the Spread (?)

Back the 49ERS (-10.5, -110) to win by 11 or more points. The Falcons are 2-4 against the spread on the road, but they’ve lost by more than 10 points five times this season. The Niners are 3-2-1 ATS at home and have won by at least 11 points six times on the year.

Over/Under (?)

San Francisco is 6-7-0 against the Over/Under, but tops the projections by an average of 2.7 PPG. Atlanta is 5-8 against the O/U while falling an average of 0.3 points shy of the projections. Take the OVER 46.5 (-115) with each side missing a top cornerback and the 49ers providing the bulk of the scoring.

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Esten’s NFL betting record: 39-41

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