Week 1 first look: East Tennessee State Buccaneers at Vanderbilt Commodores odds and lines, Vandy likely to end losing streak

Previewing the college football Week 1 matchup between the East Tennessee State Buccaneers and Vanderbilt Commodores with odds, trends and head-to-head records.

The East Tennessee State Buccaneers and Vanderbilt Commodores open their 2021 regular season Saturday at Vanderbilt Stadium. Kickoff is scheduled for 8 p.m. ET. Below, we look at the East Tennessee State vs. Vanderbilt odds and lines; check back for our college football picks and predictions.

East Tennessee State, an FCS school, played a spring football schedule, going 4-2. It played as recently as April 10, a 21-13 loss on the road to Mercer.

Vanderbilt played nine games in a COVID-shortened 2020 season, losing all nine of those outings. The offense really struggled, scoring 17 or fewer points in seven of those games.

East Tennessee State at Vanderbilt odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 8:32 a.m. ET.

  • Money line: East Tennessee State +800 (bet $100 to win $800) | Vanderbilt -1600 (bet $1,600 to win $100)
  • Against the spread/ATS: East Tennessee State +21.5, -112 (bet $112 to win $100) | Vanderbilt -21.5, -108 (bet $108 to win $100)
  • Total (Over/Under): Off the board

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2020 betting stats:

  • ML: ETSU 4-2 | Vanderbilt 0-9
  • ATS: ETSU N/A | Vanderbilt 4-5
  • O/U: ETSU N/A | Vanderbilt 4-5

East Tennessee State at Vanderbilt head-to-head

These teams last met Nov. 23, 2019 with Vanderbilt rolling to a 38-0 victory in Nashville. In fact, that was the last victory for the Commodores before a 10-game losing streak.

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