Best NFL underdog picks and predictions for Week 6

Analyzing NFL Week 6 betting odds and lines, with expert predictions and picks of the 3 best underdogs to cash in on.

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Underdogs didn’t fare so well in Week 5. Out of 14 games, only 3 underdogs (Arizona Cardinals, Dallas Cowboys and New York Giants) won straight up and another (Indianapolis Colts) covered in a loss.

As such, our Week 5 picks weren’t great. The Tampa Bay Buccaneers lost to the Atlanta Falcons in overtime and the Denver Broncos beat the Las Vegas Raiders, but the Colts covered as 3.5-point underdogs in a 3-point loss to the Jacksonville Jaguars.

Through 5 weeks, we are 7-7-1. Can we improve it?

Below, we analyze BetMGM Sportsbook NFL odds, and tab the best NFL Week 6 underdog bets to cash in on among SportbookWire’s NFL expert picks and predictions.

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NFL underdog predictions: Week 6

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Thursday at 12:10 p.m. ET. All games Sunday and ET unless noted.

JAGUARS (+110) vs. Bears in London – 9:30 a.m. (NFL Network)

The Jaguars are 6-5 all-time in London and QB Trevor Lawrence is 3-1 in 4 career starts across the pond. Their offense came alive last week with 37 points. After scoring a combined 40 points in the first 3 weeks of the season, they have scored 20 and 37.

The Chicago Bears have won 2 in a row, and rookie QB Caleb Williams is finding his stride. He has 3 TD passes and no INTs in the last 2 games. But London is a different animal, and Williams’ inexperience means the Jaguars, who play in London yearly, will have the advantage.

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BROWNS +9 (-110) at Eagles – 1 p.m. (CBS)

The Cleveland Browns are coming off a 21-point defeat, but their previous 2 losses were by no more than 6 points.

The Philadelphia Eagles were also blown out in a 17-point loss to Tampa Bay Sept. 29 and are coming off their bye. Their 2 wins have been by no more than 5 points.

Philly hasn’t scored more than 21 points in its last 3 games. Cleveland has scored between 13 and 18 every game.

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COMMANDERS +6.5 (-110) at Ravens – 1 p.m. (CBS)

The Baltimore Ravens have scored 28, 35 and 41 points in their last 3 games. But while facing good offenses like Dallas and the Cincinnati Bengals, the Ravens allowed 25 and 38 points in a pair of 3-point wins.

The Washington Commanders are rolling offensively, scoring 38, 42 and 34 points in the last 3 weeks.

The Ravens can score, but they also give up points, and the Commanders are 1st in the NFL with 31 points per game this season.

This should be a game that goes down to the wire.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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