Clemson at Notre Dame odds, picks and predictions

Analyzing Saturday’s Clemson Tigers at Notre Dame Fighting Irish odds and lines, with college football expert picks and predictions.

The No. 5 Clemson Tigers (8-0) and Notre Dame Fighting Irish (5-3) clash Saturday at Notre Dame Stadium in South Bend. Kickoff is scheduled for 7:30 p.m. ET (NBC). Below, we analyze Tipico Sportsbook‘s lines around the Clemson vs. Notre Dame odds, and make our expert college football picks and predictions.

Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.

Clemson enters this game off back-to-back, 1-score victories followed by a Week 9 bye. The Tigers, the No. 4 team in the first College Football Playoff rankings of the season, survived a somewhat shaky defensive effort in an Oct. 15 win over Florida State (34-28). They overcame 4 turnovers in an Oct. 22 victory over Syracuse (27-21).

The Fighting Irish took down Syracuse Saturday (a week after the Orange fell to Clemson). Notre Dame easily covered a 1.5-point spread in a 41-24 triumph that saw the Irish held an opposing offense under 300 total yards (286) for a 2nd straight week and a 3rd time in 4 weeks. In total defense for the season, UND ranks 28th in FBS (334.5 yards per game).

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Clemson at Notre Dame odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 12:01  p.m. ET.

  • Moneyline: Clemson -190 (bet $190 to win $100) | Notre Dame +155 (bet $100 to win $155)
  • Against the spread (ATS): Clemson -3.5 (-110) | Notre Dame +3.5 (-110)
  • Over/Under (O/U): 44.5 (O: -107 | U: -115)

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Clemson at Notre Dame picks and predictions

Prediction

Clemson 24, Notre Dame 17

Moneyline

Its likely the true odds are buried between these prices. PASS.

Against the spread

The Notre Dame run defense may be a bit overrated when looking at analytic measures. Clemson has the ground game to take advantage of this deficit.

And look for the Tigers to finish on the plus side of the field and have the havoc-causing defense to produce a short field or two.

The lean, however, is small. Consider a partial-unit play on CLEMSON -3.5 (-110).

Over/Under

Both Clemson and Notre Dame figure as perhaps a bit too far over their skis in 3rd-down defense. The Irish have been awful in red-zone defense, allowing 20 TDs in as many trips.

The weather report calls for high winds, but figure both sides being able to have enough value drives to spiral this game into the 40s by the 4th quarter.

BACK THE OVER 44.5 (-107).

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Clemson at Notre Dame odds, picks and prediction

Previewing Saturday’s Clemson Tigers at Notre Dame Fighting Irish sports betting odds and lines, with college football betting picks, tips and predictions.

The Clemson Tigers (7-0) head to South Bend, Ind. for a conference showdown against the Notre Dame Fighting Irish (6-0). The Irish are in the ACC for 2020 due to COVID-related circumstances. Kickoff is scheduled for 7:30 p.m. ET at Notre Dame Stadium. Below, we analyze the Clemson-Notre Dame college football betting odds and lines, with picks and predictions.

The Tigers are No. 1 in the Amway Coaches Poll powered by USA TODAY Sports, while the Fighting Irish are No. 4.

Also see: Clemson at Notre Dame prop predictions

Clemson at Notre Dame: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Saturday at 11:25 a.m. ET. 

  • Money line: Clemson -209 (bet $209 to win $100) | Notre Dame +170 (bet $100 to win $170)
  • Against the spread/ATS: Clemson -5.5 (-110) | Notre Dame +5.5 (-110)
  • Over/Under: 49.5 (O: -110 | U: -110)

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Clemson at Notre Dame: Three things to know

  1. QB Trevor Lawrence missed Clemson’s previous game against the Boston College Golden Eagles after testing positive for COVID Oct 28. Lawrence’s replacement—Freshman QB D.J. Uiagalelei, a five-star recruit out of Bellflower, Calif.—completed 30 of 41 passes for 342 yards and 2 touchdowns with zero interceptions and added a rushing touchdown in Clemson’s 34-28 win on Halloween.
  2. Notre Dame made quick work of the Georgia Tech Yellow Jackets last week, winning 31-13 but failed to cover as a 20.5-point favorite.
  3. According to ESPN Stats & Info, Notre Dame head coach Brian Kelly will be coaching against an AP Top-5 team for the eighth time in his career and sixth time at Notre Dame. He’s 0-7 in these games and his team has never scored more than 27 points.

Clemson at Notre Dame: Odds, betting lines, predictions and picks

Prediction

Clemson 24, Notre Dame 20

Money line (ML)

If it feels like we see Notre Dame (+170) in one of these games every year and every year the Fighting Irish come up short, well it’s because that is what usually happens.

Obviously, Clemson (-209) has also been playing and winning in these spots. The Tigers haven’t lost more than two games in a season since 2014, which is the only year they haven’t played in the College Football Playoff.

I am not betting against the Tigers here but I am also not risking more than two times my potential return for an outright win. If I was playing Clemson’s money line, I’d include it in a parlay.

Against the spread (ATS)

Both defenses can one-up each other in matchup stats. They’ve each been unbelievable this season but the Fighting Irish are at full strength whereas the Tigers will be missing several key pieces.

Clemson starting LBs James Skalski, Mike Jones Jr. and starting DT Tyler Davis will all miss Saturday’s game and DE Xavier Thomas will be suspended for the first half because of a targeting penalty in the game against Boston College.

Furthermore, since Kelly took over as head coach at Notre Dame in 2010, the Fighting Irish have a winning ATS record against ranked foes (22-20 ATS). I LEAN NOTRE DAME +5.5 because its offense could have some success in this spot.

Over/Under (O/U)

With no Lawrence in the lineup, Clemson should lean on senior RB Travis Etienne who’s having an amazing finale to his college career. Again, Notre Dame typically comes up short in big spots: The Under is 4-0 in the Fighting Irish’s last four games as a home underdog.

TAKE UNDER 49.5.

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