The Clemson Tigers (5-3, 4-2 ACC) pay a visit to Cardinal Stadium to take on the Louisville Cardinals (4-4, 2-3) Saturday at 7:30 p.m. ET. Below, we look at the Clemson vs. Louisville odds and lines; check back for our college football picks and predictions.
Clemson defeated Florida State 30-20 Saturday. The Tigers defense held the Seminoles to just 241 total yards and a combined 4-for-14 mark on third and fourth downs.
As shaky as the Clemson offense has been this season (114th FBS in total offense), the Tigers have been solid in stopping opponents. Clemson has held foes to 15.3 points per game, which ranks third nationally.
The Cardinals were on the downside of a 28-13 game at NC State Saturday. Louisville now returns home after losing three of its last four games overall. Dating back to 2020, the Cards are 5-1 in their last six home games.
Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.
Clemson at Louisville odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 5:52 p.m. ET.
- Money line: Clemson -200 (bet $200 to win $100) | Louisville +160 (bet $100 to win $160)
- Against the spread (ATS): Clemson -3.5, -112 (bet $112 to win $100) | Louisville +3.5, -108 (bet $110 to win $108)
- Over/Under (O/U): 46.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Clemson 5-3 | Louisville 4-4
- ATS: Clemson 1-7 | Louisville 4-4
- O/U: Clemson 2-6 | Louisville 2-6
Clemson at Louisville head-to-head
The all-time series is led by the Tigers 6-0. They are 4-0 ATS over the last four meetings (2016-19).
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