The Kansas City Chiefs open the 2022 NFL season on the road against the Arizona Cardinals in a Week 1 late afternoon matchup. Kickoff on Sunday, Sept. 11, is 4:25 p.m. ET (FOX) at State Farm Stadium. Below, we analyze Tipico Sportsbook‘s lines around the Chiefs vs. Cardinals odds and lines; check back for our NFL picks and predictions.
Also see: All Week 1 odds and lines
The Chiefs have won the AFC West 6 straight seasons and have been to the postseason 7 straight years. They will begin their quest to continue that run with QB Patrick Mahomes still leading the way, although this will be the first season without WR Tyreek Hill, who was traded to Miami in the offseason. Mahomes will face his former Texas Tech coach, Kliff Kingsbury, who now leads the Cardinals.
The Cardinals started last season 7-0 and 10-2, but then lost 4 of their final 5 games in the regular season and were embarrassed in the first round of the playoffs. QB Kyler Murray got a huge contract extension and now they hope to return to postseason play, only without the late-season collapse.
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Chiefs at Cardinals odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday, Aug. 29 at 12:35 a.m. ET.
- Money line (ML): Chiefs -190 (bet $190 to win $100) | Cardinals +155 (bet $100 to win $155)
- Against the spread (ATS): Chiefs -3.5 (-110) | Cardinals +3.5 (-110)
- Over/Under (O/U): 53.5 (O: -108 | U: -112)
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2021 betting stats:
- ML: Chiefs 14-6 | Cardinals 11-7
- ATS: Chiefs 10-10 | Cardinals 10-8
- O/U: Chiefs 12-8 | Cardinals 8-10
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Chiefs vs. Cardinals head-to-head
The Cardinals and Chiefs have played each other 13 times dating back to 1970. The Chiefs lead the all-time series 9-3-1.
The Chiefs have won 4 of the last 5 matchups, dating back to 2002. They last played in 2018, a 26-14 win by the Chiefs.
Mahomes is 1-0 against the Cardinals in his career. This will be Murray’s first career start against the Chiefs.
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