The Los Angeles Chargers (1-0) meet the Kansas City Chiefs (1-0) in primetime, Week 2 of the 2022 regular season.
Here are the betting odds for the matchup, per Tipico Sportsbook:
| Spread | Moneyline | Total Points | |
| Los Angeles Chargers | +4.5 | +170 | O 54.5 -108 |
| Kansas City Chiefs | -4.5 | -205 | U 54.5 -112 |
The Chargers are coming off a victory against their other division rival, the Raiders, 24-19.
Picking up where he left off last season, Justin Herbert completed 26 34 passes for 279 yards and three touchdowns. The new and improved defense was dominant – Derek Carr was sacked five times and threw three interceptions.
Meanwhile, the Chiefs controlled the Cardinals the entire contest, coming out victorious, 44-21.
Patrick Mahomes was lights out, going 30 for 39 with 360 yards, five touchdowns, and no interceptions. Kansas City’s defense, which also features fresh faces, held down Arizona, keeping them to just seven points for most of the game.
Last season, the two teams split 1-1. The Chiefs lead the series against the Chargers, 65-58-1
Thursday’s contest between Los Angeles and Kansas City will begin at 5:15 p.m. PT and be broadcasted on Prime Video.