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The Arizona Cardinals and Buffalo Bills open their seasons Sunday. Kickoff from Highmark Stadium is scheduled for 1 p.m. ET (CBS). Below, we look at Cardinals vs. Bills odds from BetMGM Sportsbook before making our expert NFL picks and predictions later in the week.
The Cardinals are coming off a second consecutive 4-win season, but are much more optimistic this time around, as QB Kyler Murray is healthy and played well in the 2nd half of last season.
The Bills are coming off another season winning the AFC East and then losing in the playoffs to the Kansas City Chiefs. They went 11-6 in the regular season and lost to the Chiefs in the divisional round of the playoffs. QB Josh Allen had 44 combined passing and rushing touchdowns last season.
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Cardinals at Bills odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:10 a.m. ET.
- Moneyline (ML): Cardinals +225 (bet $100 to win $225) | Bills -275 (bet $275 to win $100)
- Against the spread (ATS): Cardinals +6 (-110) | Bills -6 (-110)
- Over/Under (O/U): 48 (O: -115 | U: -105)
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2023 betting stats
- ML: Cardinals 4-13 | Bills 12-7
- ATS: Cardinals 9-8 | Bills 8-11
- O/U: Cardinals 10-7 | Bills 8-11
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Cardinals vs. Bills head-to-head
The Cardinals and Bills are infrequent opponents. The Cardinals won the last matchup 32-30 in Arizona in 2020 on a last-second touchdown pass from Murray to WR DeAndre Hopkins, known in Arizona as the Hail Murray.
The Bills lead the all-time series 7-5. The only time the Bills have lost to the Cardinals at home was in 1971, their first-ever meeting, when the Cardinals played in St. Louis.
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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