The San Francisco 49ers (0-0) begin their NFC West and NFC conference titles in 2020, opening the season against the Arizona Cardinals (0-0). Kickoff is at 4:25 p.m. ET at Levi’s Stadium on Sunday in front of an empty stadium.
Cardinals at 49ers betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:45 p.m. ET.
- Moneyline: Cardinals +240 (bet $100, win $240) | 49ers -295 (Bet $295, win $100)
- Against the Spread/ATS: Cardinals +6.5 (-110) | 49ers -6.5 (-110)
- Over/Under: 48.5 (O: -110, U: -110)
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Cardinals at 49ers game notes
- The 49ers swept the season series in 2019.
- Cardinals QB Kyler Murray is coming off an Offensive Rookie of the Year season in 2019.
- The 49ers lost WR Emmanuel Sanders in free agency and traded away RB Matt Breida and DL DeForest Buckner in the offseason.
- The Cardinals acquired WR DeAndre Hopkins via trade, re-signed RB Kenyan Drake and added DL Jordan Phillips, LB Devon Kennard, LB De’Vondre Campbell, LB Isaiah Simmons and CB Dre Kirkpatrick in the offseason.
Cardinals at 49ers key injuries
Cardinals
- TE Maxx Williams (ankle)
49ers
- WR Deebo Samuel (foot) doubtful
- WR Brandon Aiyuk (hamstring) questionable
- CB Jason Verrett (hamstring) doubtful
- OL Ben Garland (ankle) questionable
Cardinals at 49ers: Odds, betting lines, picks and prediction
Prediction
49ers 28, Cardinals 27
Moneyline (?)
Despite playing two close games against one another in 2019 and the Cardinals making big improvements in the offseason, the 49ers remain heavy favorites in the season opener. This feels like a game that the Cardinals are in position to sneak a victory, although I am not confident enough to say put your money on them for the big payout on the money line. As for betting the Niners, the -295 is just too rich. This game could go either way so AVOID the money line.
49ers Wire: 49ers injury report: Brandon Aiyuk returns to practice
Against the Spread (?)
The Cardinals, despite being 5-10-1 straight up in 2019, were a very solid 9-5-2 ATS. The 49ers did not cover the spread in either game against Arizona last season, and the Cardinals appear to be much improved. This is bound to be one that goes down to the wire. The result will be closer than a touchdown. Take the Cardinals +6.5 (-110).
Cardinals Wire: Cardinals to make DeAndre Hopkins highest-paid WR with extension
Over/Under (?)
These two teams blew by 50 points in their first meeting and combined for 62 points in their second contest. The Cardinals defense is better, but it is not known how much better, while their offense should put up points. This pick is easy. Pound the OVER 48.5 POINTS.
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