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The Arizona Cardinals (3-6-1) are on the road to face the San Francisco 49ers (8-1) for the second time in three weeks in this NFC west battle. The game kicks off at 4:05 p.m. ET at Levi’s Stadium in Santa Clara, Calif. The game will air on FOX.
We analyze the Cardinals-49ers odds and sports betting lines, while providing betting tips and advice on this Week 11 NFL matchup.
Cardinals at 49ers: Week 11 preview, betting trends and notes
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- The 49ers lost for the first time in this season in Week 10, a 27-24 overtime loss at home to the Seattle Seahawks.
- Cardinals RB Kenyan Drake rushed for 110 yards and a touchdown and had 162 total yards against the 49ers two weeks ago.
- Cardinals QB Kyler Murray had three touchdown passes last week and was intercepted for the first time in over a month. He set an NFL rookie record with 211 consecutive passes without an interception.
- 49ers QB Jimmy Garoppolo threw four touchdown passes and had 317 passing yards against the Cardinals in Week 9.
- The Cardinals have scored at least 25 points in five of the last six games. The 49ers have only given up more than 25 points twice all season.
Cardinals at 49ers: Key injuries
Cardinals: DE’s Jonathan Bullard (foot) and Rodney Gunter (calf), LB Terrell Suggs (hamstring) and CB Patrick Peterson (calf) are questionable. RB Chase Edmonds (hamstring) is out.
49ers: WR Dante Pettis (back) and LB Azeez Al-Shaair (concussion) are questionable. WR Emmanuel Sanders (ribs) and TE George Kittle (knee) are doubtful. OT Joe Staley (finger), RB Matt Breida (ankle) and DT D.J. Jones (groin) are out.
Cardinals at 49ers: Odds, betting lines and prediction
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:50 p.m. ET.
Prediction
49ers 28, Cardinals 27
Moneyline (?)
AVOID. At -500, the San Francisco 49ers are almost a sure thing, but it will win you almost nothing. A $10 bet will only earn a $2 profit. However, the Cardinals at +370 make one heck of a value, but considering the imbalanced matchup, it isn’t worth the wager.
Against the Spread (?)
The 49ers are favored by 11.5 (+100) points at home. They are 5-4 ATS this season, while the Cardinals have been an impressive 7-3 ATS. The Cardinals are bad defensively, but the 49ers are missing enough weapons on offense to keep from pulling ahead by a bunch. The Cardinals offense is scoring enough to keep them in the game. Take the CARDINALS at +11.5 (-121).
Over/Under (?)
The total is set at 45.5, which seems low. While the 49ers are allowing only 14.3 points per game, good for second in the league, the Cardinals have scored at least 25 in five of the last six games, including against the 49ers two weeks ago. The Cardinals allow 28.1 points per game. Games involving the Cardinals have hit the Over in six of 10 games. Take the OVER (+100) in this one.
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