The Buffalo Bills (8-3) and San Francisco 49ers (5-6) hook up in the Week 13 Monday Night Football game, to be played at State Farm Stadium (home of the Arizona Cardinals) in Glendale, Ariz., at 8:15 p.m. ET. Due to recent Santa Clara County, Calif., COVID-19 protocol rules, the game had to be moved from the 49ers’ regular home of Levi’s Stadium – they’ll still be the designated home team. Here’s a look at the early betting odds and lines at BetMGM Sportsbook.
The Bills covered as 4.5-point favorites in a 27-17 home win vs. the Los Angeles Chargers in Week 12. QB Josh Allen threw for a touchdown and ran for another as the Bills built a 24-6, third-quarter lead before the AFC East leaders had to hold on for the win. Allen finished with 157 passing yards (18 of 24 pass attempts) with 1 TD vs. 1 pick, while rushing for 32 yards on 9 carries. RB Devin Singletary finished with a game-high 82 rushing yards on 11 carries.
PK Robbie Gould‘s 42-yard field as time expired lifted the underdog 49ers (+5.5) to a 23-20 road upset of the Los Angeles Rams last week. QB Nick Mullens finished with 252 passing yards (24 of 35) with no touchdowns and one interception, but he steered two fourth-quarter scoring drives to help the 49ers snap a 3-game losing streak. San Francisco led 17-6 with 2:38 to go in the third quarter, but LA scored two quick touchdowns to grab a 20-17 lead with 14:17 remaining in the fourth before Gould kicked 2 field goals down the stretch. 49ers WR Deebo Samuel finished with a game-high 11 catches and 133 receiving yards.
Bills at 49ers: Betting odds, spread and line
Odds via BetMGM; last updated Tuesday at 10:40 a.m. ET.
- Money line: Bills -134 (bet $134 to win $100) / 49ers +115 (bet $100 to win $115) | Bet now
- Against the spread: Bills -2.5, -115 (bet $115 to win $100) / 49ers +2.5, -106 (bet $106 to win $100) | Bet now
- Total: 47.5, Over -115 (bet $115 to win $100) / Under -106 (bet $106 to win $100) | Bet now
Betting stats:
- ATS: Bills 6-5 | 49ers 5-6
- O/U: Bills 7-3-1 | 49ers 5-6
New to NFL betting?
At -134 odds, the Bills have an implied win probability of 57.26% or 50/67 fractional odds. To cover the spread, Buffalo must win by 3 or more points for a Bills -2.5 (-115) ATS wager to win.
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The 49ers’ +115 money line represents an implied win probability of 46.51% or 23/20 fractional odds. San Francisco must win outright or keep the game within 2 points in a loss for a 49ers +2.5 (-106) ATS ticket to cash
Also see:
- Takeaways from Week 12 win vs. Chargers (Bills Wire)
- 49ers to play at least next 2 home games in Arizona (Niners Wire)
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