The Buffalo Bills (6-4) and New Orleans Saints (5-5) clash in a Thanksgiving Day battle at Caesars Superdome. Kickoff in the holiday Thursday tilt is slated for 8:20 p.m. Below, we look at the Bills vs. Saints odds and lines; check back for our NFL picks and predictions.
Buffalo lost to Indianapolis Sunday and has dropped two of its last three games. The Colts dealt the Bills a 41-15 setback at home, and the 41 points marked the most Buffalo had allowed in a single game since Oct. 13, 2020, when they gave up 42 against the Tennessee Titans. The Bills turned the ball over four times Sunday.
The Saints suffered their third consecutive defeat as they lost 40-29 at Philadelphia Sunday. New Orleans was a minus-2 in turnover differential and was undone by the Eagles going 12-of-21 on third down.
Thursday’s game pits a Saints team ranked 24th in total offense (321.3 yards per game) against a Bills defense ranked first in yards allowed per game (283.7).
Also see: All Week 12 odds and lines
Bills at Saints odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 7:35 a.m. ET.
- Money line: Bills -210 (bet $210 to win $100) | Saints +170 (bet $100 to win $170)
- Against the spread (ATS): Bills -4.5, -108 (bet $108 to win $100) | Saints +4.5, -112 (bet $112 to win $100)
- Over/Under (O/U): 46.5, O: -112 (bet $112 to win $100) | U: -108 (bet $108 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Bills 6-4 | Saints 5-5
- ATS: Bills 5-4-1 | Saints 5-5
- O/U: Bills 5-5 | Saints 6-4
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Bills at Saints head-to-head
Buffalo and New Orleans are meeting for the first time since 2017. The Saints won that game 47-10 in Buffalo. New Orleans has won five straight against the Bills dating back to 2001 and is 7-4 all-time against Buffalo in a series that dates to 1973.
New Orleans is 5-1 ATS over the last six games of this series.
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