The No. 3 Ohio State Buckeyes (1-0) will take on the No. 17 Penn State Nittany Lions (0-1), Saturday, at 7:30 p.m. E.T. at Beaver Stadium. We analyze the Ohio State-Nittany Lions college football betting odds and lines, with picks and best bets.
The Buckeyes are the third-ranked team in college football and Penn State is No. 17, according to the Amway Coaches Poll powered by USA TODAY Sports.
Ohio State at Penn State Betting odds, spread and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 5:15 p.m. ET.
- Money line: Ohio State -400 | Penn State +310
- Against the spread/ATS: Ohio State -11.5 (-110) | Penn State +11.5 (-110)
- Over/Under: 64.5 (O: -110 | U: -110)
Ohio State at Penn State: Three things to know
- In the first game of the season, Ohio State QB Justin Fields completed 20 of 21 passes for 276 yards and two touchdowns. During his college career, he’s thrown 47 touchdowns to just three interceptions.
- Ohio State has won 19 of their last 20 games with their last loss coming against Clemson in the College Football Playoff last season.
- Penn State has failed to cover the spread in any of their last five home games.
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Ohio State at Penn State: Odds, prediction, betting lines and picks
Prediction
Ohio State 42, Penn State 25
Money line (ML)
OHIO STATE (-400) is a huge money line favorite over Penn State in this one, but it’s fair to be cautious about betting on the Buckeyes considering the odds. However, this is a safe bet here as the Buckeyes might be the best team in college football. Look for this game to be over early in Happy Valley.
Against the spread (ATS)
OHIO STATE -11.5 (-110) is a double-digit favorite over Penn State in this contest and that feels low. With Heisman-hopeful QB Justin Fields under center for the Buckeyes, look for them to score into the 40s as their offense is among the best in college football. With several potential first-round picks on defense as well, look for the Buckeyes to win and cover on Saturday evening.
Over/Under (O/U)
The total for this Big Ten matchup is set at 64.5, which is among the highest-ever between these two teams. But considering the firepower on both offenses, don’t be surprised if the OVER hits. Ohio State could easily score into the mid-40s and if Penn State can score a few touchdowns, take the OVER 64.5 (-110) here.
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