The AFC East race is coming down to the wire and there’s no bigger game than Sunday’s matchup between the New England Patriots (9-5) and Buffalo Bills (8-6). Kickoff will be at 1 p.m. ET Sunday afternoon at Gillette Stadium. Below, we look at the Bills vs. Patriots odds and lines; check back for our NFL picks and predictions.
The Bills snapped their two-game losing streak Sunday with a 31-14 win over the Carolina Panthers, getting back on track after losing five of their previous eight games.
Buffalo still hasn’t won back-to-back games since Week 4 and 5, but at 8-6, the Bills are still right in the thick of things in the AFC.
The Patriots fell to the Colts Saturday night, which snapped their seven-game winning streak. As 1-point underdogs, the Patriots lost 27-17, finally coming back down to earth after a remarkable stretch of wins.
New England still holds a one-game lead on Buffalo and already beat the Bills in Week 13, but a loss will complicate things in the AFC East.
Also see: All Week 16 odds and lines
Bills at Patriots odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 2:30 p.m. ET.
- Money line: Bills +110 (bet $100 to win $110) | Patriots -135 (bet $135 to win $100)
- Against the spread (ATS): Bills +2.5, -105 (bet $105 to win $100) | Patriots -2.5, -115 (bet $115 to win $100)
- Over/Under (O/U): 43.5, O: -108 (bet $108 to win $100) | U: -112 (bet $112 to win $100)
Also see: Betting 101
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2021 betting stats:
- ML: Bills 8-6 | Patriots 9-5
- ATS: Bills 7-6-1 | Patriots 9-5
- O/U: Bills 7-7 | Patriots 6-8
Bills at Patriots head-to-head
The Bills and Patriots have squared off 123 times in their history, and one team has a clear edge. The Patriots are 77-45-1 all-time against the Bills and have won eight of the last 10 meetings. However, Buffalo has had the edge more recently, winning two of the last three since 2020.
These teams already squared off once in Week 13, a game the Patriots won 14-10 in bad weather conditions. But, the Bills have played the Pats tough since QB Josh Allen really took his game to the next level in 2020.
In the last 10 games between these teams, the Patriots are 6-3-1 ATS and the Over is just 4-6. The Patriots have outscored the Bills by an average of 23.4-16.1 in their last 10 games.
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