First look: Buffalo Bills at Indianapolis Colts odds and lines

Looking at Sunday’s Buffalo Bills at Indianapolis Colts Week 10 NFL odds, lines and trends. Here’s what you need to know.

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The Buffalo Bills (7-2) visit the Indianapolis Colts (4-5) in Week 10 on Sunday. Kickoff from Lucas Oil Stadium is scheduled for 1 p.m. ET (CBS). Below, we look at Bills vs. Colts odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The Bills have won 4 games in a row after narrowly taking down the Dolphins 30-27 on Sunday while failing to cover as 6-point home favorites. QB Josh Allen went 25-of-39 for 235 yards with 3 TDs an INT.

The Colts have lost back-to-back games after falling 21-13 against the Vikings on Sunday night and failing to cover as 5.5-point road underdogs. QB Joe Flacco went 16-of-27 for 179 yards with an INT in the loss.

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Bills at Colts odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Monday at 9:47 a.m. ET.

  • Moneyline (ML): Bills -225 (bet $225 to win $100) | Colts +180 (bet $100 to win $180)
  • Against the spread (ATS): Bills -4.5 (-110) | Colts +4.5 (-110)
  • Over/Under (O/U): 47 (O: -110 | U: -110)

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2024 betting stats

  • ML: Bills 7-2 | Colts 4-5
  • ATS: Bills 5-4 | Colts 7-2
  • O/U: Bills 5-4 | Colts 3-6

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Bills vs. Colts head-to-head

The Bills and Colts have squared off 71 times since 1970 with the Bills leading the series 37-33-1. They have played 5 times since 2015 with the Bills leading 3-2 while the Colts lead 3-2 ATS.

The last time they faced each other was in November of 2021 with the Colts winning 41-15 and covering as 7.5-point road underdogs as the Over of 49.5 easily hit.

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