Best NFL Week 6 gambling picks and predictions

SportsbookWire’s NFL Week 6 picks: ML, ATS and O/U predictions for all games

The SportsbookWire staff makes their NFL Week 6 picks and predictions for moneylines, spreads and totals.

Before looking at SportsbookWire staff’s Week 6 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com.

At 5-0 ATS, the Minnesota Vikings — 5-0 straight-up, too — are the only NFL team perfect against the spread. In Week 5, they covered as 2.5-point favorites behind a 23-17 win vs. the New York Jets in London. With a Week 6 bye, the perfect ATS record will stay intact at least for another week.

Four teams are 4-1 ATS. They are the Denver Broncos, Indianapolis Colts, Kansas City Chiefs and Washington Commanders. The Chicago Bears are 3-1-1 ATS and the Detroit Lions are 3-1 ATS.

On the flip side, the Carolina Panthers, Cleveland Browns, LA Rams and Miami Dolphins are each 1-4 ATS. The Tennessee Titans are 1-3 ATS, while the Houston Texans, New England Patriots and Seattle Seahawks are each 1-3-1 ATS.

Houston visits New England Sunday at 1 p.m. ET (CBS). As of Thursday, 1:48 p.m. ET, Houston is the 2nd-biggest favorite on the Week 6 schedule, listed at -7 (-105) by BetMGM Sportsbook’s NFL odds. The Browns are 9.5-point underdogs to the Philadelphia Eagles.

When it comes to totals, the LA Chargers are 0-4 O/U. Houston, Miami, Minnesota, the New York Giants and Pittsburgh Steelers are each 1-4 O/U, while the Jets are 1-3-1 O/U and the Lions are 1-3 O/U.

Five teams have been solid Over plays at 4-1 O/U. They are the Baltimore Ravens, Carolina, Cincinnati Bengals, Seattle and Washington.

Joining Minnesota on a bye week are Kansas City, the Rams and Miami.

NFL Week 6 staff picks

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds and check out more NFL expert picks and predictions from SportsbookWire.com.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Follow SportsbookWire on Twitter/X and like us on Facebook.

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SportsbookWire’s NFL Week 6 picks: ML, ATS and O/U predictions for all games

The SportsbookWire staff makes their NFL Week 6 picks and predictions for moneylines, spreads and totals.

Before looking at SportsbookWire staff’s Week 6 NFL picks, here’s where things stand.

There are 2 remaining undefeated teams — the San Francisco 49ers and Philadelphia Eagles are both 5-0. To remain unbeaten, they’ll have to do so on the road in Week 6.

The 49ers visit the Cleveland Browns (2-2) and the Eagles face the New York Jets (2-3) — both as favorites Sunday on FOX — at 1 p.m. ET and 4:25 p.m. ET, respectively.

The Carolina Panthers (0-5) are the lone winless team and it doesn’t look promising this Sunday. QB Bryce Young and Co. are double-digit road underdogs when they face the Miami Dolphins (4-1) and their top-ranked offense, led by QB Tua Tagovailoa at 1 p.m. ET (CBS).

Thursday kicked off with the Kansas City Chiefs (5-1) winning at home 19-8 — and covering by the hook as 10.5-point favorites — over the Denver Broncos (1-5).

The Baltimore Ravens (3-2) and Tennessee Titans (2-3) continue the International Series with a Sunday tilt at London’s Tottenham Hotspur Stadium — 9:30 a.m. ET (NFL Network).

Sunday night’s game features the Buffalo Bills (3-2) hosting the New York Giants (1-4) at 8:20 p.m. ET (NBC).

The week wraps up with the Dallas Cowboys (3-2) at the Los Angeles Chargers (2-2) in the Monday Night Football matchup at SoFi Stadium — 8:15 p.m. ET (ABC/ESPN).

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NFL Week 6 staff picks

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list and check out more NFL expert picks and predictions from SportsbookWire.com.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW. Access more betting odds at BetMGM Sportsbook.

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