Arizona Cardinals at Seattle Seahawks odds, picks and prediction

Analyzing Sunday’s Arizona Cardinals at Seattle Seahawks odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (8-2) are on the road in Week 11 to face the Seattle Seahawks (3-6) for the first time this season. Kickoff for this NFC West showdown is 4:25 p.m. ET at Lumen Field. Below, we look at the Cardinals vs. Seahawks odds and lines, and make our best NFL picks, predictions and bets.

The Seahawks have lost four of their last five games and were shut out 17-0 by the Green Bay Packers last week in QB Russell Wilson‘s return from injured reserve. They sit in last place in the NFC West and are banged up. Three defensive starters are questionable for the game and starting RB Chris Carson will not return this season.

The Cardinals have lost two of their last three games and played the last two weeks without QB Kyler Murray and WR DeAndre Hopkins, who have missed time with injuries. They beat the San Francisco 49ers and lost to the Carolina Panthers with QB Colt McCoy starting the last two weeks. The Cardinals are 5-0 on the road this season.

Cardinals at Seahawks odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:22 a.m. ET.

  • Money line: Cardinals +122 (bet $100 to win $122) | Seahawks -150 (bet $150 to win $100)
  • Against the spread (ATS): Cardinals +2.5 (+102) | Seahawks -2.5 (-125)
  • Over/Under (O/U): 45.5 (O: -112 | U: -108)

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Cardinals at Seahawks key injuries

Cardinals

  • WR DeAndre Hopkins (hamstring) out
  • OL Justin Pugh (calf) out
  • QB Kyler Murray (ankle) questionable
  • DT Corey Peters (shoulder) questionable
  • Budda Baker (heel) questionable

Seahawks

  • CB D.J. Reed (knee, groin) questionable
  • Jamal Adams (groin) questionable
  • DE Kerry Hyder (calf) questionable

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Cardinals at Seahawks odds, lines, predictions and picks

Prediction

Cardinals 24, Seahawks 20

Money line

This ultimately comes down to whether the Cardinals get Murray back or not. Considering the Cardinals’ success on the road (5-0) and Seattle’s struggles at home (1-3), the line is likely unsure about whether he will play.

The Cardinals have scored over 30 points in every road game this season, including against the San Francisco 49ers with McCoy at quarterback.

The Seahawks are 31st in yards allowed, so the Cardinals will not struggle offensively.

Take the CARDINALS (+122).

Against the spread

The Cardinals are 7-3 ATS this season but are a perfect 5-0 ATS on the road. They have won every road contest by double digits.

Seattle is 2-2 ATS at home this season.

This is not a great matchup for Seattle. They don’t allow many points but give up a ton of yards, but the Cardinals are very effective offensively. The Seahawks also don’t run the ball well, and that is the Cardinals’ defensive weakness, and backup RB Alex Collins is banged up with starter Carson ruled out for the year just this week.

Take the CARDINALS +2.5 (+102).

Over/Under

The Cardinals have put up over 30 points seven times this season and in all five of their road games. However, only three of those five games hit the Over because they also have allowed 20 or fewer points in every one of those games.

The Seahawks are 1-8 on the Over/Under this season with the lone Over hitting in a home game against the Tennessee Titans in Week 2.

Take UNDER 45.5 (-108).

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Arizona Cardinals at Seattle Seahawks odds, picks and prediction

Previewing the Arizona Cardinals at Seattle Seahawks Week 11 betting odds and lines, with NFL betting picks, tips and predictions.

The Arizona Cardinals (6-3) and Seattle Seahawks (6-3) kick off Week 11 in the NFL with an NFC West showdown with playoff implications on Thursday Night Football. Kickoff is at 8:20 p.m. at CenturyLink Field in Seattle. Below, we preview the Cardinals-Seahawks betting odds and lines and make our NFL picks and predictions.

Cardinals at Seahawks: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 7:05 a.m. ET.

  • Money line: Cardinals +140 (bet $100 to win $140) | Seahawks -162 (bet $162 to win $100)
  • Against the spread/ATS: Cardinals +3 (-115) | Seahawks -3 (-106)
  • Over/Under: 57.5 (O: -110 | U: -110)

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Cardinals at Seahawks: Game notes

  • The Cardinals have the league’s No. 1 offense in terms of yards, gaining 425.4 total yards per contest.
  • The Seahawks are the league’s top-scoring team with an average of 32.2 points scored per game.
  • Seahawks QB Russell Wilson has a league-leading 28 touchdown passes this season, but was intercepted by the Cardinals three times in Week 7 and has thrown multiple interceptions in three of his last four games.
  • Seattle has lost three of its last four games, allowing 34.66 points per game in those three losses.
  • Cardinals QB Kyler Murray has 17 touchdown passes and 10 rushing touchdowns this season and has had at least one of each in eight of nine games this year.

Cardinals at Seahawks: Key injuries

Cardinals

  • OL Justin Murray (hand) out
  • DL Corey Peters (knee) out
  • DL Jordan Phillips (hamstring) out
  • LB De’Vondre Campbell (calf) questionable
  • TE Darrell Daniels (ankle) questionable
  • Charles Washington (groin) questionable
  • TE Maxx Williams (ankle) questionable

Seahawks

  • WR Tyler Lockett (knee) questionable
  • CB Quinton Dunbar (knee) out
  • CB Shaquill Griffin (hamstring) out
  • RB Chris Carson (foot) questionable
  • OL Ethan Pocic (concussion) out
  • CB Neiko Thorpe (core) out/IR
  • Jordan Simmons (calf) out
  • RB Travis Homer (knee, thumb) doubtful

Cardinals at Seahawks: Odds, betting lines, predictions and picks

Prediction

Cardinals 33, Seahawks 27

Money line (?)

Both teams have the same record but Arizona has had uncanny success in Seattle, losing only once there since 2013. Seattle’s defense is bad to begin with and depleted with injuries, while the Cardinals offense is healthy and is able to move the ball against anyone.

Arizona is also 3-0 straight up as underdogs this season, so go with that trend. Take CARDINALS (+140).

Against the spread (?)

The Cardinals have been money as underdogs. They have covered the spread and won outright all three games this season in which they were underdogs. Seattle is a respectable 4-3 ATS as the favorites, but they are playing too poorly on defense against a potent Cardinals attack.

Take CARDINALS +3 (-115).

Over/Under (?)

The Cardinals had their first six games go Under the projected point total to start the season, but they have gone Over in each of their last three contests. The last Cardinals-Seahawks game went Over and Seattle is 6-3 O/U. This feels like a lock. Take OVER 57.5 (-110).

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