The Arizona Cardinals (8-2) are on the road in Week 11 to face the Seattle Seahawks (3-6) for the first time this season. Kickoff for this NFC West showdown is 4:25 p.m. ET at Lumen Field. Below, we look at the Cardinals vs. Seahawks odds and lines, and make our best NFL picks, predictions and bets.
The Seahawks have lost four of their last five games and were shut out 17-0 by the Green Bay Packers last week in QB Russell Wilson‘s return from injured reserve. They sit in last place in the NFC West and are banged up. Three defensive starters are questionable for the game and starting RB Chris Carson will not return this season.
The Cardinals have lost two of their last three games and played the last two weeks without QB Kyler Murray and WR DeAndre Hopkins, who have missed time with injuries. They beat the San Francisco 49ers and lost to the Carolina Panthers with QB Colt McCoy starting the last two weeks. The Cardinals are 5-0 on the road this season.
Cardinals at Seahawks odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:22 a.m. ET.
- Money line: Cardinals +122 (bet $100 to win $122) | Seahawks -150 (bet $150 to win $100)
- Against the spread (ATS): Cardinals +2.5 (+102) | Seahawks -2.5 (-125)
- Over/Under (O/U): 45.5 (O: -112 | U: -108)
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Cardinals at Seahawks key injuries
Cardinals
- WR DeAndre Hopkins (hamstring) out
- OL Justin Pugh (calf) out
- QB Kyler Murray (ankle) questionable
- DT Corey Peters (shoulder) questionable
- S Budda Baker (heel) questionable
Seahawks
- CB D.J. Reed (knee, groin) questionable
- S Jamal Adams (groin) questionable
- DE Kerry Hyder (calf) questionable
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Cardinals at Seahawks odds, lines, predictions and picks
Prediction
Cardinals 24, Seahawks 20
Money line
This ultimately comes down to whether the Cardinals get Murray back or not. Considering the Cardinals’ success on the road (5-0) and Seattle’s struggles at home (1-3), the line is likely unsure about whether he will play.
The Cardinals have scored over 30 points in every road game this season, including against the San Francisco 49ers with McCoy at quarterback.
The Seahawks are 31st in yards allowed, so the Cardinals will not struggle offensively.
Take the CARDINALS (+122).
Against the spread
The Cardinals are 7-3 ATS this season but are a perfect 5-0 ATS on the road. They have won every road contest by double digits.
Seattle is 2-2 ATS at home this season.
This is not a great matchup for Seattle. They don’t allow many points but give up a ton of yards, but the Cardinals are very effective offensively. The Seahawks also don’t run the ball well, and that is the Cardinals’ defensive weakness, and backup RB Alex Collins is banged up with starter Carson ruled out for the year just this week.
Take the CARDINALS +2.5 (+102).
Over/Under
The Cardinals have put up over 30 points seven times this season and in all five of their road games. However, only three of those five games hit the Over because they also have allowed 20 or fewer points in every one of those games.
The Seahawks are 1-8 on the Over/Under this season with the lone Over hitting in a home game against the Tennessee Titans in Week 2.
Take UNDER 45.5 (-108).
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