Arizona Cardinals vs. Los Angeles Rams odds predictions pick betting line spread

Arizona Cardinals at Los Angeles Rams odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Los Angeles Rams odds and lines, with expert NFL picks and predictions.

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The Arizona Cardinals (1-4) and Los Angeles Rams (2-3) look to bounce back from Week 5 losses when they square off Sunday at SoFi Stadium. This rivalry game between NFC West foes is set for 4:25 p.m. ET (FOX). Below, we analyze BetMGM Sportsbook’s lines around the Cardinals vs. Rams odds, and make our expert NFL picks and predictions.

The Cardinals have dropped each of their last 2 games, losing to the San Francisco 49ers and Cincinnati Bengals by 19 and 14 points, respectively. They’re in last place in the NFC West at 1-4, 1 game behind the Rams, who are 2-3. QB Josh Dobbs continues to fill in for the injured Kyler Murray, while Arizona will also be without starting RB James Conner.

The Rams fell to the Philadelphia Eagles last week, 23-14, to drop their record below .500 for the 2nd time this season. They’re trying to avoid their second 2-game losing streak of the season, facing a Cardinals team that they’re 11-2 against since 2017.

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Cardinals at Rams odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 10:54 p.m. ET.

Moneyline (ML): Cardinals +240 (bet $100 to win $240) | Rams -300 (bet $300 to win $100)
Against the spread (ATS): Cardinals +7 (-115) | Rams -7 (-105)
Over/Under (O/U): 47.5 (O: -110 | U: -110)

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Cardinals at Rams key injuries

Cardinals

WR Marquise Brown (illness) questionable
RB James Conner (knee) out
S Jalen Thompson (hamstring) out

Rams

LB Ernest Jones (knee) questionable
DT Larrell Murchison (knee) questionable
OL Joe Noteboom (groin) questionable

Cardinals at Rams picks and predictions

Prediction

Rams 27, Cardinals 17

Moneyline

This is the 1st time all season the Rams have been favored by more than 1 point, playing 4 of their first 5 games as underdogs to their opponents. This is a game they should win against a team that many thought would be the worst in the NFL before the season began.

However, it’s hard to feel confident enough in a Rams team that barely beat the Colts to bet them at -300 on the money line. PASS on the ML.

Against the spread

The Rams are 3-1-1 ATS this season, with their only loss coming last week against the Eagles in a 9-point defeat as 4-point underdogs. The Cardinals are a respectable 3-2 ATS and upset the Dallas Cowboys SU in Week 3, a 28-16 win, while also almost beating the Commanders and Giants in the first 2 weeks.

Arizona will be severely shorthanded without Conner, which is part of the reason the Rams look even more enticing at -7. BET RAMS -7 (-105) to cover the spread and win by at least 8 points at home, having gone 7-2-1 ATS against the Cardinals in the last 10 meetings.

Over/Under

The Over is 2-3 in the Rams’ 5 games this season but it’s 4-1 in the Cardinals’ contests thus far. Los Angeles’ offense has disappeared in the 2nd half of games this season, scoring only 1 touchdown in the 2nd half and overtime in the last 4 weeks.

Without Conner, the Cardinals’ scoring output should be lower, too. BET UNDER 47.5 (-110).

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Arizona Cardinals at Los Angeles Rams odds, picks and predictions

Analyzing Sunday’s Arizona Cardinals at Los Angeles Rams odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (3-6) and Los Angeles Rams (3-5) will meet on Sunday afternoon as both teams attempt to get their frustrating seasons back on track. Kickoff from SoFi Stadium will be at 4:25 p.m. ET (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Cardinals vs. Rams odds, and make our expert NFL picks and predictions.

The Cardinals have lost 4 of their last 5 games after starting the year 2-2, dropping their last 2 against the Minnesota Vikings and Seattle Seahawks. Their defense has allowed the 2nd-most points per game (26.8) in the NFL this season and only ranks 16th in points scored (22.6). The Cardinals already lost once to the Rams this season, falling 20-12 in Week 3.

The Rams have been equally disappointing, starting the year 3-5 after losing their last 2 games to the San Francisco 49ers and Tampa Bay Buccaneers. The defense has allowed the 8th-fewest yards per game (312.4) but the offense is scoring just 16.4 points per game, which is 29th.

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Cardinals at Rams odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:24 a.m. ET.

Moneyline (ML): Cardinals +110 (bet $100 to win $110) | Rams -130 (bet $130 to win $100)
Against the spread (ATS): Cardinals +2.5 (-109) | Rams -2.5 (-111)
Over/Under (O/U): 39.5 (O: -113 | U: -107)

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Cardinals at Rams key injuries

Cardinals

S Budda Baker (ankle) questionable
OL Max Garcia (shoulder) out
OL Rodney Hudson (knee) out
OT D.J. Humphries (back) questionable
QB Kyler Murray (hamstring) questionable

Rams

NT Greg Gaines (elbow) doubtful
LT Alaric Jackson (knee) doubtful
CB Robert Rochell (illness) questionable
QB Matthew Stafford (concussion) questionable

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Cardinals at Rams picks and predictions

Prediction

Rams 21, Cardinals 17

Moneyline

With question marks about both teams’ quarterbacks, it’s hard to predict what either offense will look like on Sunday. If both are healthy and active, I like the Rams straight-up at home against a team they’re 11-1 against since 2017. However, if the Rams are without Stafford, this is a toss-up.

With so much uncertainty surrounding these teams, I’m going to PASS on the moneyline.

Against the spread

The Cardinals are currently +2.5 with Murray and Stafford questionable. The Rams opened as 3.5-point favorites before the quarterback injuries were reported earlier this week.

Murray seems to have a better chance to play than Stafford because of the fact that Stafford is in the concussion protocol, so I would take the CARDINALS +2.5 (-109) as of now.

Over/Under

The Over/Under opened at 43 points but has since dropped to 39.5 due to injury concerns. Regardless of which quarterback(s) play on Sunday, I like the UNDER 39.5 (-107) in this game. These offenses are just struggling too badly right now.

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Arizona Cardinals at Los Angeles Rams odds, picks and prediction

Analyzing Monday’s Arizona Cardinals at Los Angeles Rams Wild Card odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (11-6) face the Los Angeles Rams (12-5) in the first Monday playoff game in NFL history as the NFC West rivals face off in an NFC Wild Card matchup. Kickoff is set for 8:15 p.m. ET at SoFi Stadium (on ABC and ESPN). Below, we look at the Cardinals vs. Rams odds and lines, and make our best NFL picks, predictions and bets.

The division foes split their two games this season with Arizona winning 37-20 at SoFi Stadium in Week 4, and Los Angeles claiming a 30-23 road victory in Week 14. The Cardinals started 7-0 but weathered injuries late in the season and lost four of their final five games to end up as the conference’s No. 5 seed.

The Rams lost their final game of the regular season but won their previous five. In his first season with the team, QB Matthew Stafford passed for 4,886 yards and 41 touchdowns. WR Cooper Kupp led the NFL in receiving yards (1,947), receptions (145) and touchdown catches (16).

Also see: Wild Card Weekend picks and predictions

Cardinals at Rams odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 8:48 p.m. ET.

Money line: Cardinals +155 (bet $100 to win $155) | Rams -190 (bet $190 to win $100)
Against the spread (ATS): Cardinals +3.5 (-110) | Rams -3.5 (-110)
Over/Under (O/U): 49.5 (O: -115 | U: -105)

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Cardinals at Rams key injuries

Cardinals

RB James Conner (ribs) questionable
WR Rondale Moore (ankle) questionable
DL Jordan Phillips (knee) questionable
OL Justin Pugh (calf) questionable
CB Marco Wilson (shoulder) questionable

Rams

S Taylor Rapp (concussion) out
WR Van Jefferson (shoulder) questionable

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Cardinals at Rams odds, lines, predictions and picks

Prediction

Cardinals 31, Rams 24

Money line

TAKE THE CARDINALS (+155) for the upset.

The Cardinals will be getting back some defensive reinforcements. They should have Wilson back in the secondary, and both Phillips and DE J.J. Watt, expected to be activated from injured reserve, on the interior. Watt and Phillips are the Cardinals’ two best interior rushers.

With the Rams secondary and linebacking corps shorthanded – down their two starting safeties and a starting linebacker – the Cardinals will be able to attack the middle of the field and pressure the L.A. defense.

In the Cardinals’ Week 4 win, they did not sack Stafford, but they did hit him several times, leading to erratic throws. Stafford (287 passing yards, 3 TDs) was nearly perfect in Week 14, but the Rams only won by seven points.

Against the spread

TAKE THE CARDINALS +3.5 (-110).

The Cardinals were 10-7 ATS overall and 8-1 ATS on the road this season. The Rams went 8-9 ATS in the regular season and 4-4 ATS at home.

Ten of the Rams’ 12 wins were over non-playoff teams. Against teams in the postseason, they went 2-5, while the Cardinals went 5-2 against playoff teams.

Over/Under

This one seems like a gimme. TAKE OVER 49.5 (-115).

Both games between the two teams went over 50 points.

Plus, the Cardinals scored 30 or more points in nine games this season, while the Rams did it seven times.

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Arizona Cardinals at Los Angeles Rams odds, picks and prediction

Analyzing Sunday’s Arizona Cardinals at Los Angeles Rams odds and lines, with expert NFL picks, predictions and best bets.

The Arizona Cardinals (3-0) carry their unblemished record into Sunday’s matchup with the undefeated Los Angeles Rams (3-0), for a big early-season NFC West tilt at SoFi Stadium. Kickoff is set for 4:05 p.m. ET. Below, we look at the Cardinals vs. Rams odds and lines, and make our best NFL picks, predictions and bets.

The Cardinals are off to a fantastic start, winning each of their first three games. They lead the NFL in scoring with an average of 34.3 points per game, also checking in at No. 11 in total defense. QB Kyler Murray already has 10 total touchdowns and is averaging 335 passing yards per game, emerging as an MVP frontrunner in the early part of the season.

The Rams have been equally impressive. New QB Matthew Stafford has 9 touchdowns and just 1 interception, looking every bit like the star the Rams thought he’d be when they acquired him. The defense has played well, too, limiting the Tampa Bay Buccaneers to only 24 points – including a late garbage-time touchdown – last week.

Also see: Week 4 staff picks

Cardinals at Rams odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 5:15 p.m. ET.

Money line: Cardinals +175 (bet $100 to win $175) | Rams -220 (bet $220 to win $100)
Against the spread (ATS): Cardinals +4.5 (-108) | Rams -4.5 (-112)
Over/Under (O/U): 54.5 (O: -105 | U: -115)

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Cardinals at Rams key injuries

Cardinals

OT Kelvin Beachum (ribs) questionable
OL Justin Murray (back) questionable
OL Justin Pugh (back) questionable
RB Eno Benjamin (hamstring) out

Rams

RB Darrell Henderson Jr. (ribs) questionable
WR Tutu Atwell (illness) doubtful

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Cardinals at Rams odds, lines, predictions and picks

Prediction

Rams 30, Cardinals 27

Money line

The Rams are 8-0 against the Cardinals since 2017 and have outscored them 251-91. It’s as lopsided as any head-to-head matchup of the last four seasons, with Los Angeles owning Arizona since Sean McVay took over as head coach.

This is a much better Cardinals team than the one the Rams crushed in the last four years, but Los Angeles is still the better group on paper and on the field.

Bet the RAMS (-220) to win outright at home.

Against the spread

The Rams and Cardinals are both 2-1 ATS, each with two double-digit wins and another by just 3 or fewer points. Although there have been seven double-digit wins by the Rams in the last eight games against Arizona, I expect this one to be closer.

Bet the CARDINALS +4.5 (-108) to cover the spread and keep this one within a field goal.

Over/Under

The total has gone Over in each of the Rams’ first three games, mostly because the offense has scored on more than half of their possessions thus far. The Cardinals have the highest-scoring offense in the league and can be susceptible to the run on defense, which is why the line is on the higher side.

Bet the OVER 54.5 (-105).

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Underdog corner: 3 best NFL ATS picks and predictions for Week 4

Assessing the NFL betting odds and lines for Week 4, with three predictions and picks for the best underdog ATS bets to make.

Our unblemished record fell by the wayside last Sunday as the New York Jets failed to cover the 10.5-point spread on the road against the Denver Broncos. (Deep analysis: Covering is almost always tougher when a team doesn’t score.) Below, we look at the top NFL underdog picks and predictions of Week 4.

Nevertheless, we hit on the New Orleans Saints and Los Angeles Chargers, who both won outright on the road, to improve to 8-1 against the spread on the season. Seven of our nine underdog picks so far have notched straight-up, wins as well.

Jump aboard for Week 4 to see if we can keep the train rolling.

Also see: All Week 4 odds and lines

NFL underdog predictions: Week 4

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 4:25 p.m. ET.

Carolina Panthers +4.5 (-115) at Dallas Cowboys

QB Dak Prescott and the Cowboys were certainly impressive in their 2021 Big D debut Monday night, smashing the rival Philadelphia Eagles 41-21 to improve to 2-1 straight up and 3-0 against the spread.

The Panthers will be without injured do-it-all running back Christian McCaffrey so why are we on Carolina here in this meeting of 3-0 ATS teams? Three reasons:

The Panthers have a distinct rest advantage having last played a week ago Thursday night.
The Carolina defense has been an underrated force so far, leading the league in sacks (14), total QB pressures (47) and rushing defense (45 yards allowed per game, 2.6 yards per carry).
It’s an obvious letdown spot for the Cowboys coming off an emotional, prime-time rout of a division rival.

Dallas likely still wins, but the Panthers keep it close and cover.

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Arizona Cardinals +4.5 (-110) at Los Angeles Rams

Two of the league’s five unbeaten teams clash in this early battle for NFC West supremacy.

The Rams have dominated the series of late, winning eight straight — all by at least 7 points — and going 7-0-1 ATS. Much like the Cowboys, the Rams are in a prime letdown spot coming off a big home win over Tom Brady and the defending Super Bowl champion Tampa Bay Buccaneers.

Dangerous dual-threat QB Kyler Murray and the Cards, who are tied with the Bucs for the league scoring lead at 34.3 points per game, present a different kind of challenge and certainly have enough firepower to keep this one close.

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Las Vegas Raiders +3.5 (-115) at Los Angeles Chargers

QB Derek Carr and the Raiders take their 3-0 record west for a Monday night division tussle with QB Justin Herbert and the 2-1 Bolts.

The Silver & Black won and covered in three of the last four meetings and in what figures to be a close game where Raiders fans will be in the majority at SoFi Stadium, go ahead and take the 3.5 points.

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