The Arizona Cardinals (8-6) host the San Francisco 49ers (5-9) in one of three Saturday games in Week 16. Kickoff is at 4:30 p.m. ET at State Farm Stadium in Glendale, AZ. Below, we give you five player/team prop bets between the two teams to consider from the BetMGM game menu in Week 16.
Also see: San Francisco 49ers at Arizona Cardinals odds, picks and prediction
49ers at Cardinals Week 16 prop bet predictions
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:50 a.m. ET.
Cardinals WR DeAndre Hopkins OVER 81.5 receiving yards (-110)
Hopkins leads the NFL in receiving yards with 1,324 this season. He had 151 receiving yards in Week 1 against the 49ers and has seven games of over 100 yards. He has had at least 136 yards in each of the last two games and the 49ers will be without their top cover corner.
Cardinals RB Kenyan Drake OVER 54.5 rushing yards (-110)
Drake is coming off only 26 yards on 10 carries in Week 15, but, using the 54.5-yard mark as a baseline, Drake has alternated going Over and Under that mark in each of his last eight games. He is due to go Over. He has rushed for at least 60 yards in his last three games against the 49ers dating back to last season when he was acquired by the Cardinals.
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49ers TE George Kittle OVER 50.5 receiving yards (-110)
Kittle is returning for his first game since Week 8, coming off injured reserve. He will be QB C.J. Beathard‘s No. 1 target, as they will be without WR Deebo Samuel and RB Raheem Mostert. Kittle had 44 receiving yards in one half of play against the Cardinals in Week 1 before leaving with a knee injury, but has had more than 50 yards in all three of his previous games against the Cardinals, dating back to the 2018 season. The trend will continue.
Cardinals QB Kyler Murray OVER 1.5 TD passes (-165)
Murray has 26 touchdown passes this season. He has eight games this season with multiple touchdown passes, including three in two of his last three and last week against a depleted Philadelphia Eagles secondary. The 49ers’ secondary is equally depleted and they have allowed at least two touchdown passes in three of the last four games.
49ers QB C.J. Beathard OVER 0.5 interceptions throw (-190)
49ers quarterbacks have thrown interceptions in six straight games. They have turned the ball over multiple times in eight straight games and in 10 of their last 11. Beathard has thrown at least one interception in eight of his 10 career starts and will be without his best receiver and running back.
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