First look: Arizona Cardinals at Carolina Panthers odds and lines

Looking at Sunday’s Arizona Cardinals at Carolina Panthers Week 4 NFL odds, lines and trends. Here’s what you need to know.

The Arizona Cardinals (1-2) are on the road in Week 4 to take on the Carolina Panthers (1-2) Sunday. Kickoff is set for 4:05 p.m. ET at Bank of America Stadium (FOX). Below, we look at Cardinals vs. Panthers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

The Cardinals suffered a 20-12 home loss to the Los Angeles Rams in Week 3. They have lost 6 straight games at State Farm Stadium. Arizona fell behind 13-0 and never scored a touchdown despite outgaining Los Angeles (365-339). It was the 11th time the Cards lost to the Rams in their last 12 matchups.

The Panthers picked up their first win of the year Sunday with a 22-14 home victory over the New Orleans Saints. They had a season-high 293 yards of offense and the defense forced 3 turnovers and scored a fumble-recovery touchdown. RB Christian McCaffrey had 108 rushing yards and QB Baker Mayfield had a touchdown pass in the win.

Also seeAll Week 4 odds and lines

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Cardinals at Panthers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 11:40 a.m. ET.

  • Money line (ML): Cardinals -101 (bet $101 to win $100) | Panthers -117 (bet $117 to win $100)
  • Against the spread (ATS): Cardinals +1.5 (-112) | Panthers -1.5 (-108)
  • Over/Under (O/U): 44.5 (O: -105 | U: -115)

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2022 betting stats

  • ML: Cardinals 1-2 | Panthers 1-2
  • ATS: Cardinals 1-2 | Panthers 1-2
  • O/U: Cardinals 2-1 | Panthers 1-2

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Cardinals vs. Panthers head-to-head

Including 3 postseason matchups, this will be the 20th time the two teams have played. The Panthers have dominated this series 14-5 and have won the last 6 meetings, including twice in the playoffs.

The Cardinals have not beaten the Panthers since 2013; Carolina won last season’s meeting in a 34-10 blowout. New Panthers QB Baker Mayfield is 0-2 against the Cardinals in his career.

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