New Orleans Saints big favorites at home vs. San Francisco 49ers in Week 10

The New Orleans Saints are the betting favorites in their Week 10 home game with the San Francisco 49ers.

The San Francisco 49ers (4-5) visit the New Orleans Saints (6-2) in Week 10. Kickoff is Sunday at 4:25 p.m. ET. Here’s a look at the early betting odds and lines at BetMGM Sportsbook.

The undermanned 49ers lost 34-17 at home to the Green Bay Packers in the Week 9 Thursday Night Football game as 6-point underdogs. With numerous injuries and WR Kendrick Bourne‘s positive COVID-19 test, which also sidelined three other 49ers for high-risk contacts, San Francisco was no match for Green Bay.

Among the injured who sat were QB Jimmy Garoppolo (ankle), All-Pro TE George Kittle (foot), RB Raheem Mostert (ankle), WRs Deebo Samuel (hamstring) and Brandon Aiyuk (COVID contact), DE Nick Bosa (knee) and CB Richard Sherman (calf).

QB Nick Mullens started in place of Garoppolo, throwing for 291 yards with a touchdown and one pick. Bourne has since tested negative and there’s hope several of the players out due to contact tracing will be back for Week 10.

The Saints went into Tampa, Fla., and manhandled the Buccaneers 38-3 in the Week 9 Sunday Night Football game as 3.5-point underdogs. QB Drew Brees threw for 222 yards and 4 touchdowns as New Orleans won a fifth consecutive game, took over first place in the NFC South and completed a season sweep of rival Tampa Bay.

Brees’ first 3 TDs, RB Alvin Kamara‘s 1-yard TD run and a Wil Lutz FG helped the Saints build a 31-0 lead by halftime. The Saints defense held the Bucs to just 8 rushing yards (on 5 carries) and didn’t allow them to score until there was 5:52 to go. It was also the first Under game the Saints played in 2020 – they entered with a 7-0 Over/Under record.

49ers at Saints: Betting odds, spread and line

Odds via BetMGM; last updated Tuesday at 7:40 a.m. ET.

  • Money line: 49ers +330 (bet $100 to win $330) / Saints -417 (bet $417 to win $100) | Bet now
  • Against the spread: 49ers +9.5, -110 (bet $110 to win $100) / Saints -9.5, -110 (bet $110 to win $100) | Bet now
  • Total: 49.5, Over -115 (bet $115 to win $100) / Under -106 (bet $106 to win $100) | Bet now

New to NFL betting?

At +330 odds, the 49ers have an implied win probability of 23.26% or 33/10 fractional odds. To cover the spread, San Francisco must win outright or stay within 9 points in a loss for a 49ers +9.5 ATS ticket to cash.

Place your legal, online NFL bets in CO, IN, NJ, TN and WV at BetMGM. Risk-free first bet! Terms and conditions apply. Bet now!

The Saints’ -417 money line represents an implied win probability of 80.66% or 100/417 fractional odds. New Orleans must win by 10 or more points for a Saints -9.5 (-110) ATS wager to win.

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