San Francisco 49ers at New England Patriots odds, picks and prediction

Previewing the San Francisco 49ers at New England Patriots Week 7 betting odds and lines, with NFL betting picks, tips and predictions.

The San Francisco 49ers (3-3) travel across the country to take on the New England Patriots (2-3) Sunday in a Week 7 showdown between two teams who have underperformed thus far. Kickoff from Gillette Stadium is at 4:25 p.m. ET. Below, we analyze the 49ers-Patriots Week 7 matchup, including the betting odds, spread and lines, and look at the best NFL betting options.

49ers at Patriots betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 11:33 p.m.

  • Money line: 49ers +105 (bet $100, win $105) | Patriots -125 (bet $125, win $100)
  • Against the spread/ATS: 49ers +1.5 (-110) | Patriots -1.5 (-110)
  • Over/Under: 43.5 (O: -110, U: -110)

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49ers at Patriots game notes

  • The Patriots have covered in four of the last five head-to-head meetings vs. the 49ers.
  • The Patriots are below .500 after five games for the first time since 2002 and have lost three of their last four after beating the Miami Dolphins in Week 1.
  • The 49ers are 2-0 on the road this season and covered the spread in both of those games.
  • The total has gone Over in three of the 49ers first six games but only twice in the Patriots’ five games.
  • The 49ers and Patriots both rank outside the top 19 in points scored, but they’re both in the top 11 in rushing yards, with New England ranking second.

49ers at Patriots key injuries

49ers

  • LB Kwon Alexander (ankle) questionable
  • RB Raheem Mostert (ankle) questionable
  • S Jaquiski Tartt (groin) questionable
  • OT Trent Williams (ankle) questionable

Patriots

  • DT Adam Butler (shoulder) probable
  • S Kyle Dugger (ankle) probable
  • WR Julian Edelman (knee) probable
  • OG Shaq Mason (calf) probable

49ers at Patriots: Odds, prediction, betting lines and picks

Prediction

49ers 24, Patriots 20

Money line (?)

The 49ERS (+105) may have gotten off to a slow start, but they’ve looked better than the Patriots thus far. They’ve been banged up all over the offense and defense, yet they were still able to knock off the Los Angeles Rams last week. They can still run the ball consistently and should be able to do so against an average Patriots run defense. As long as Patriots head coach Bill Belichick doesn’t completely take away 49ers TE George Kittle, the 49ERS (+105) will win this game.

Against the spread (?)

The 49ers have to travel across the country for this game, which is part of the reason they’re considered underdogs. However, the Patriots offense is really struggling with Cam Newton at quarterback and a host of unproductive receivers. The 49ers should cover the spread in this one, especially considering they’re getting 1.5 points. Take SAN FRANCISCO (-1.5).

Over/Under (?)

The Over/Under of 43.5 is the lowest of the Week 7 slate, which is an indicator of how poorly these offenses are playing and how good their defenses have looked. Despite losing DLs Nick Bosa and Solomon Thomas, the 49ers defense has held strong. The total will go OVER on Sunday, but just barely.

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