St. Louis Cardinals at Chicago Cubs odds, picks and best bets

Previewing Monday’s St. Louis Cardinals at Chicago Cubs sports betting odds and lines, with MLB betting picks, tips and best bets.

The St. Louis Cardinals (17-15) close out a five-game set with the Chicago Cubs (23-18) with a Labor Day matinee at 4:10 p.m. ET at Wrigley Field. Below, we analyze the Cardinals-Cubs MLB betting odds and lines, with picks and best bets.

Cardinals at Cubs: Projected starting pitchers

RHP Johan Oviedo vs. RHP Kyle Hendricks

Oviedo is a big, right-handed, rookie fire-baller making his fourth career start. A Cards’ top-15 prospect, the 22-year-old owns a 4.30 ERA and 0.96 WHIP through 14 2/3 innings

  • Has allowed a mere .195 batting average on balls in play, and that’s not the only metric that foreshadows some trouble. Batted-ball data indicates a 50% hard-hit rate which is high.

Hendricks has registered a 3.78 ERA and 1.12 WHIP through 50 innings. The consistent right-hander owns a sub-2.50 ERA over his home starts the last two years (2019-20).

  • Averages 95 pitches per start and figures to help a Cubs bullpen in closing out a taxing weekend.
  • Current St. Louis batters own an aggregate .631 OPS, .109 isolated power against the 11-year veteran.

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Cardinals at Cubs: Key injuries

(Get the latest injury news here.)

Cardinals

  • RP Jordan Hicks (elbow) out
  • OF Dexter Fowler (illness) out

Also see: BaseballHQ Fantasy Baseball

Cardinals at Cubs: Odds, lines, picks and betting tips

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 1 p.m. ET.

Moneyline (ML)

The Redbirds are a strong play despite the surface look of the starting pitching matchup. The usually solid Hendricks has had some hiccups when following a 100-pitch outing and/or back-to-back efforts over 95. The last nine times that scenario has applied, the next-time-out start has resulted in a 6.33 ERA.

On the whole, the Cubs’ record is over-performing production by a few clicks; the opposite holds true for a St. Louis nine. The price on the visitors is right: Back the CARDINALS (+160).

New to sports betting? A winning $100 bet on the Cardinals returns a $160 profit.

Run line/Against the spread (ATS)

The run line tag on St. Louis — +1.5 (-143) — is a bit pricey. PASS.

Over/Under (O/U)

Monday’s Wrigley Field weather calls for a seasonal low-70s temp, low humidity, and a double-digit pitcher’s breeze in from center. The lean here is slight and on the UNDER 7.5 (-110).

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