The Sportsbook Wire team is here to help you with your Week 2 NFL picks. Our writers offer up their selections on the money line, spread and Over/Under for every game on the Week 2 slate. Visit SportsbookWire.com for more NFL picks and predictions throughout the season.
It was a wild Week 1 in the NFL with nine underdogs winning straight up and 12 of 16 covering the spread. The Over went 7-9 against the projected totals after 2020’s early run of high scores in the absence of proper training camps and preseason play.
Check out our staff predictions before locking in your Week 2 NFL picks.
NFL Week 2 staff picks
2021-22 season standings
Odds by Tipico Sportsbook.
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