South Alabama at Louisiana odds, picks and predictions

Analyzing Saturday’s South Alabama at Louisiana odds and lines, with college football expert picks, predictions and best bets.

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The South Alabama Jaguars (4-5, 3-2 Sun Belt) and Louisiana Ragin’ Cajuns (8-1, 5-0) tussle in a Saturday night in Lafayette. The opening kickoff will be at 7 p.m. ET (ESPN+). Let’s analyze BetMGM Sportsbook’s college football odds around the South Alabama vs. Louisiana odds, and make our expert college football picks and predictions.

South Alabama heads into this contest off a bye week. The Jaguars last played Nov. 2 when they logged a 34-30 loss as a 6-point favorite against Georgia Southern. USA was a minus-2 in turnovers and lost the game despite outgaining the Eagles 458 yards to 337.

Louisiana is 6-0 straight up and 4-2 against the spread (3-0 ATS since Oct. 19) over its last 6 games. Last week, the Cajuns cruised to a 55-14 triumph — easily covering a -14 — against Arkansas State. ULL leads the Sun Belt in offense (456.2 yards per game) and is second in defense (335.4 yards per game).

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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South Alabama at Louisiana odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated at 9:35 a.m. ET.

  • Moneyline: South Alabama +220 (bet $100 to win $220) | Louisiana -275 (bet $275 to win $100)
  • Against the spread (ATS): South Alabama +7 (-105) | Louisiana -7 (-115)
  • Over/Under (O/U): 59.5 (O: -115 | U: -105)

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South Alabama at Louisiana picks and predictions

Prediction

Louisiana 34, South Alabama 24

Moneyline

Lots of juice. Little interest. No profit margin. PASS.

Against the spread

USA is 2-5 ATS in its last 7 road games. The Jaguars are 1-5 ATS in their last 6 visits to Cajun Field.

Louisiana defeated South Alabama 33-20 last season, covering as an 11.5-point road favorite. The Cajuns benefited from 5 takeaways in that game. The 2024 Jaguars have been responsible with the football (just 6 giveaways), but USA could be without its game-manager QB Gio Lopez, who is questionable with a concussion.

ULL is on a roll and has especially been in firm control of its games played on home turf. The Cajuns are a solid play to close this one out in 2-score territory.

TAKE LOUISIANA -7 (-105).

Over/Under

The Under has cashed in 4 straight series meetings and is 4-1 in South Alabama’s last 5 road tilts.

ULL’s pass defense has been significantly better at home, allowing just 161.7 yards per game (21st FBS).

Still, overall peg this total as being a well-made one. Consider a partial-unit play on a slight UNDER 59.5 (-105) lean.

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