Seattle Mariners at Chicago White Sox odds, picks and predictions

Analyzing Wednesday’s Seattle Mariners at Chicago White Sox odds and lines, with MLB expert picks and predictions.

The Seattle Mariners (2-3) and Chicago White Sox (3-1) meet Wednesday at Guaranteed Rate Field. First pitch is set for 7:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Mariners at White Sox odds with MLB picks and predictions.

Season series: White lead 1-0 after taking Tuesday’s series opener 3-2

Seattle has slashed a .183/.291/.299 in scoring just 12 runs in 5 games.

Chicago is 54-28 (.659) over its last 82 games at home.

Mariners at White Sox: Projected starters

Mariners LHP Robbie Ray vs. White Sox LHP Dallas Keuchel

Ray (1-0, 1.29 ERA) is tabbed for his second start. He has a 1.00 WHIP, 5.1 BB/9 and 6.4 K/9 through 7 IP.

  • Logged a 2.84 ERA in 32 starts last season for the Toronto Blue Jays
  • Has held current Chicago batters to a whiff-laden .708 OPS

Keuchel (2021: 9-9, 5.28 ERA) is lined up for his season debut. Last year he notched a 1.53 WHIP, 3.3 BB/9 and 5.3 K/9 through 162 IP.

  • Current Seattle bats own a .741 OPS against him
  • Owns a career 2.96 ERA in April and March

Mariners at White Sox odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:48 p.m. ET.

  • Money line: Mariners +100 (bet $100 to win $100) | White Sox -120 (bet $120 to win $100)
  • Against the spread (ATS): Mariners -1.5 (+160) | White Sox +1.5 (-200)
  • Over/Under (O/U): 8.5 (O: -135 | U: +110)

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Mariners at White Sox prediction and picks

Prediction

Mariners 5, White Sox 4

Money line

The Mariners have some untapped offensive potential on their half of the ledger. The White Sox pitching and defense have a bit over their heels early. With Ray on the bump, SEATTLE (+100) is a decent play.

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Run line/Against the spread

PASS.

Over/Under

With some fade baked in against the starters, and the potential for some weather-induced, batter-friendly conditions in the latter innings, BACK THE OVER (-135).

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