San Francisco 49ers at New York Giants odds, picks and best bets

Previewing the Week 3 matchup between the S.F. 49ers and New York Giants betting odds and lines, with NFL betting picks, tips and best bets.

A banged-up San Francisco 49ers (2-0) hope to stay unbeaten as they travel to take on the New York Giants (0-2) at MetLife Stadium on Sunday at 1 p.m. ET. Within, we analyze the 49ers-Giants betting odds, spread and lines while giving betting tips around the matchup.

49ers at Giants betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 11:30 a.m. ET.

  • Moneyline: Giants +155 (bet $100, win $155) | Giants -182 (Bet $182, win $100)
  • Against the Spread/ATS: Giants +3.5 (-110) | 49ers -3.5 (-110)
  • Over/Under: 41.5 (O: -110, U: -110)

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49ers at Giants game notes

  • Giants QB Daniel Jones has three interceptions in two games.
  • The 49ers lost DE Nick Bosa and DT Solomon Thomas to season-ending knee injuries last week.
  • The Giants are averaging a league-low 14.5 points in two games.
  • Giants RB Saquon Barkley suffered a season-ending knee injury last week.

49ers at Giants key injuries

49ers

  • QB Jimmy Garoppolo (ankle) doubtful
  • RB Raheem Mostert (knee) doubtful
  • RB Tevin Coleman (knee) doubtful
  • TE George Kittle (knee) questionable
  • LB Dre Greenlaw (quad) questionable

Giants

  • DB Adrian Colbert (quad) questionable

49ers at Giants: Odds, betting lines, picks and prediction

Prediction

49ers 23, Giants 16

Moneyline (?)

This is a tough game to gauge because the 49ers are missing so many players and the Giants have been so bad. However, Nick Mullens, has starting experience, can produce in the passing game, while the Giants do not have Barkley and don’t protect Daniel Jones well. Take the 49ERS -182.

Against the Spread (?)

Both teams are 1-1 ATS. While I believe the 49ers (-3.5) will win, there are too many unknowns to be confident in any pick around the spread, which is trending down after being 4 points previously. AVOID.

Over/Under (?)

The 49ers will keep the Giants’ scoring low. The question is whether the 49ers offense will produce without their quarterback, receivers, top two backs and perhaps their All-Pro tight end. Take the UNDER 41.5.

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