Rams open as 4.5-point road favorites vs. 49ers in Week 10

The Rams and 49ers are both coming off bad losses, but it’s Los Angeles that opens as the favorite in this Week 10 matchup.

Week 9 was not kind to the Rams or 49ers. They both lost on Sunday, each in fairly embarrassing fashion: The Rams to the Titans, 28-16, and the 49ers to Arizona, 31-17. What makes these two losses even worse is that their opponents were without their best players. The Titans didn’t have Derrick Henry, and the Cardinals were without both Kyler Murray and DeAndre Hopkins.

Next up, the Rams and 49ers will square off in Week 10 on Monday Night Football. Despite their disappointing performances on Sunday, the Rams opened as the favorites on the road against the 49ers.

According to Tipico Sportsbook, the Rams are 4.5-point favorites over the 49ers. The over/under is set at 49.5 points, while the Rams moneyline is -210 and the 49ers’ is +160. If you were to bet on the Rams to win outright, a $210 wager would return a profit of $100.

The Rams have lost four straight games to the 49ers dating back to 2019, so they’ll be trying to snap an ugly losing streak against their division rivals.

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