Rams at 49ers: 5 key matchups to watch in Week 16

Andrew Whitworth will have his hands full with Nick Bosa.

Cory Littleton vs. 49ers’ RBs

(Photo by John McCoy/Getty Images)

The 49ers have the second-best rushing attack in the NFL, averaging 147 yards per game. Most years, that would lead the league, but the Ravens are in another world with Lamar Jackson. The Rams were run over by Ezekiel Elliott and Tony Pollard last week, allowing 263 yards rushing to the Cowboys.

San Francisco’s ground game is even better than Dallas’, which is bad news for the Rams. Littleton will be tested not only as a run defender, but also in coverage against the 49ers’ tailbacks. If he doesn’t have at least 10 tackles in this one, it’ll be a surprise.