Andrew Whitworth vs. Nick Bosa
Bosa is a top candidate for Defensive Rookie of the Year and is in the running for Defensive Player of the Year, too. He’s a force at right end and consistently wins his pass-rush reps in a variety of ways, from his speed to his power. Whitworth will be tasked with stopping the rookie, which will prove difficult on Saturday night.
Whitworth has been playing much better lately than he was when the Rams and 49ers first met this season, but so is Bosa. This is a marquee matchup on the left side of the line and will play a huge role in the outcome of this game.