Rams at 49ers: 4 key things to know for Week 16 matchup

The Rams and 49ers will square off for the second time this season on Saturday night.

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The Rams and 49ers will meet for the 141st time in their history on Saturday night, a series San Francisco leads 70-67-3. The 49ers have rolled to an 11-3 record this season, while Los Angeles is only 8-6 and clinging to its last hope of making the playoffs.

The Rams need a win in order to stay alive in the NFC, but San Francisco is a tough opponent – one that beat the Rams 20-7 in Week 6 already.

Here are six things to know about this upcoming matchup in Week 16.

McVay never loses to same team twice in a season

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In his first three seasons, Sean McVay has had remarkable success against the NFC West. Though his Rams are just 2-2 in the division this season, they were 6-0 in 2018 and 4-2 in 2017. One thing McVay has never done is lose to the same opponent twice in a season, which is something he’ll try to avoid on Saturday night.

The 49ers beat the Rams 20-7 in their first meeting and will try to make it two in a row against Los Angeles this weekend. Considering how good the 49ers have been, this could very well be the first time McVay loses to the same team twice in the same year.