As exciting as the Rams’ 17-point win over the Seahawks was in Week 1, they’re already onto their next challenge: the 49ers. San Francisco has won eight straight regular-season games against the Rams and comes into this game as a 7.5-point favorite.
The odds are stacked against Los Angeles in this divisional matchup, especially with Cooper Kupp still out. If the Rams can pull off the upset, it’ll be a massive statement to the rest of the NFL.
That won’t be easy, and here are the five biggest concerns heading into Sunday’s matchup at SoFi Stadium.