The San Francisco 49ers (6-10) head to State Farm Stadium to take on the Arizona Cardinals (7-9) to close their 2024 NFL season.
The 49ers will look to end the season on an uptick before heading into an offseason with plenty of important decisions to be made. Brock Purdy’s future with the 49ers and whether or not an extension gets ironed out will be one of the primary storylines surrounding San Francisco’s offseason.
Any final evaluations of Purdy won’t happen on Sunday. Purdy is sidelined with a right elbow injury and the 49ers will turn to Joshua Dobbs as its starting quarterback.
In the two team’s first meeting this season, San Francisco built a 23-10 halftime lead before watching Arizona quarterback Kyler Murray rally the Cardinals back in the second half en route to a 24-23 Arizona victory.
As kickoff approaches, here’s a look at the betting odds, including the point spread, money line figures and the over-under point total. Plus, a prediction on how this one plays out.
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49ers vs. Cardinals game odds:
All NFL Odds via BetMGM:
- Point spread: Arizona -4.5
- Money line: Arizona -225 / San Francisco +185
- Over-under: 42.5
49ers vs. Cardinals injury updates:
- 49ers QB Brock Purdy – OUT (right elbow)
- 49ers OL Spencer Burford – OUT (calf)
- 49ers WR Deebo Samuel Sr. – OUT (rib, wrist)
- 49ers DL Robert Beal Jr. – OUT (ankle)
- 49ers DB Deommodore Lenoir – OUT (shoulder)
- 49ers TE George Kittle – Questionable (ankle, hamstring)
- Cardinals K Matt Prater – OUT (left knee)
- Cardinals OT Jackson Barton – Questionable (ankle)
- Cardinals WR Michael Wilson – Questionable (hamstring)
- Cardinals LB Mack Wilson – Questionable (ankle, quadricep)
- Cardinals CB Sean Murphy-Bunting – Questionable (toe)
49ers vs. Cardinals prediction, pick
Prediction: Arizona 27, San Francisco 20
Arizona has starting quarterback Kyler Murray as a go, while San Francisco will be without Brock Purdy. That’s enough to lean the Cardinals’ direction in this regular season finale.
Consider both Kyler Murray (+110) and 49ers running back Isaac Guerendo (+150) as anytime touchdown scorers. With several key pass-catchers potentially out of the equation and 49ers quarterback Brock Purdy as well, if San Francisco finds offensive success, there’s a good chance it’s Guerendo finding his way into the end zone.
49ers vs. Cardinals channel, start time, streaming:
The 49ers vs. Cardinals game starts at 1:25 p.m. PT and can be seen on Fox. Play-by-play broadcaster Chris Myers and color analyst Mark Schlereth will call the game from the booth at State Farm Stadium, with Jen Hale reporting from the sidelines.
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Get more betting analysis and predictions at Sportsbook Wire.