Portland Trail Blazers at Cleveland Cavaliers odds, picks and prediction

Previewing Wednesday’s Portland Trail Blazers at Cleveland Cavaliers NBA odds and lines, with basketball picks, tips and predictions.

The Portland Trail Blazers (36-29) wrap up a six-game road trip against the Cleveland Cavaliers (21-44) Wednesday at Rocket Mortgage FieldHouse. Tip-off is set for 7:30 p.m. ET. Below, we analyze the Trail Blazers-Cavaliers odds and lines, with NBA picks and predictions.

The Trail Blazers won the first four games of its road trip before running out of steam in a 123-114 loss in Atlanta Monday. The loss also slapped the brakes on a 4-0 ATS run for Portland. The Over has hit in four of their past five.

The Cavaliers gave the Suns all they could handle Tuesday night, eventually falling 134-118 in overtime. It was a tough pill to swallow for Cleveland side bettors catching 12.5 points. The Cavs have dropped seven in a row, and they have failed to cover in each outing.

Trail Blazers at Cavaliers: Odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 7:40 a.m. ET.

  • Money line: Trail Blazers -650 (bet $650 to win $100) | Cavaliers +475 (bet $100 to win $475)
  • Against the spread/ATS: Trail Blazers -11 (-110) | Cavaliers +11 (-110)
  • Over/Under: 226.5 (O: -110 | U: -110)

Trail Blazers at Cavaliers: Key injuries

Trail Blazers

  • PF Zach Collins (ankle) out
  • PG Damian Lillard (foot) probable
  • SG Norman Powell (knee) questionable

Cavaliers

  • PG Matthew Dellavedova (neck) out
  • PG Darius Garland (ankle) questionable
  • C Isaiah Hartenstein (concussion) out
  • PF Larry Nance Jr. (thumb) out
  • SF Taurean Prince (ankle) out
  • PF Lamar Stevens (concussion) out
  • SG Dylan Windler (knee) out

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Trail Blazers at Cavaliers: Odds, lines, predictions and picks

Prediction

Trail Blazers 125, Cavaliers 104

Money line (ML)

The Trail Blazers (-650) would cost you six-and-a-half times your potential return, and that’s risky business on the road. The Cavaliers (+475) are horrible, and they’re awfully dinged up down the stretch, too. Still, AVOID.

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Against the spread (ATS)

The TRAIL BLAZERS -11 (-110) are laying double digits, and that’s normally super risky for a road team. But the Cavaliers +11 (-110) just played a draining, emotional game against the Suns less than 24 hours ago, and they lost in overtime. They’ll have nothing left for the boys from Rip City.

Over/Under (O/U)

OVER 226.5 (-110) is the lean here, although play it very, very lightly. The Cavs might have some heavy legs after playing overtime in Tuesday’s loss.

The Over is 4-1 in the past five for Portland and 4-1 in the past five on the road, too. The Over is also 4-1 for Cleveland in its past five at home and 5-1 in the past six against winning sides.

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