5. Doug Pederson vs. 49ers DC Robert Saleh
Saleh is in his 16th NFL season as a coach and fourth as the 49ers defensive coordinator. He has one of the NFL’s top units and that’s without some of the game’s elite playmakers like Bosa, Dee Ford, and Richard Sherman.
Like Carson Wentz, Doug Pederson has to get out of his own head and call a perfect game. The run-pass ratio at 65% run, with Sanders playing a huge role in the passing game as well. What he can’t do is subject Carson Wentz to another 52 pass attempts with a makeshift line and a left tackle making his first NFL start.