The San Francisco 49ers (2-1) host the Philadelphia Eagles (0-2-1) on Sunday Night Football in Week 4. Kickoff at Levi’s Stadium will be at 8:20 p.m. ET. Below, we preview the Eagles-49ers Week 4 betting odds and lines and make our NFL picks and best bets.
Eagles at 49ers betting odds and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 9:30 a.m. ET.
- Money line: Eagles +250 (bet $100, win $250) | 49ers -304 (Bet $304, win $100)
- Against the spread/ATS: Eagles +7 (-110) | 49ers -7 (-110)
- Over/Under: 45.5 (O: -110, U: -110)
Sunday Night Football Special Betting Promotion!
Bet $1 on either the Philadelphia Eagles or San Francisco 49ers money line, WIN $100 (in free bets) if either team scores a touchdown in their matchup.
Place your legal, online NFL sports bets online in CO, IN, NJ and WV at BetMGM, The King of Sportsbooks! Terms and conditions apply. Bet now!
Eagles at 49ers game notes
- The Eagles are coming off a 23-23 tie against the Cincinnati Bengals at Lincoln Financial Field. The 49ers won back-to-back road games at MetLife Stadium where they beat the New York Jets and New York Giants by scores of 31-13 and 36-9, respectively.
- 49ers QB Nick Mullens filled in for an injured Jimmy Garoppolo in Week 3 and completed 25 of 36 passes for 343 yards and a touchdown in his first start since 2018.
- Philadelphia has been held below 20 points in two of three games.
- The 49ers suffered a 24-20 upset loss against the NFC West rival Arizona Cardinals in their season opener at Levi’s Stadium.
- The Eagles are 0-3 against the spread and failing to cover by a league-worst 13.7 points per game. The Niners are 2-1 ATS and cover by 8.0 PPG.
Eagles at 49ers key injuries
Eagles
- TE Dallas Goedert (ankle) IR
- WR Jalen Reagor (thumb) IR
- WR DeSean Jackson (hamstring) questionable
- OT Lane Johnson (ankle) questionable
- RB Miles Sanders (glute) probable
49ers
- DL Dee Ford (back) questionable
- QB Jimmy Garoppolo (ankle) doubtful
- LB Dre Greenlaw (quadriceps) questionable
- RB Raheem Mostert (knee) doubtful
Eagles at 49ers: Odds, betting lines, picks and prediction
Prediction
49ers 31, Eagles 20
Money line (?)
The reigning NFC champs have taken advantage of a soft early-season schedule while battling through what should be a devastating rash of injuries. TE George Kittle (knee) is expected back for Week 4 in the Niners’ return to Levi’s Stadium and rookie WR Brandon Aiyuk is coming off a breakout performance against the Giants.
Mullens will have more than enough firepower to lead the 49ers (-304) to a third straight win, but this price is too steep for an injury-riddled team on both sides of the ball. The price on the Eagles (+250) is intriguing, but their injury situation only continues to worsen and there’s little hope for their turnaround to start on the West Coast coming off an ugly tie.
PASS on the money line and get better value on the Niners on the spread.
Against the spread (?)
The emergency of Aiyuk and return of Kittle should allow the 49ERS -7 (-110) to get to 30 points for the third straight week and the Eagles won’t be able to keep pace.
There’s fear the back door will be open for much of the second half of this one, but the Niners will build a safe enough lead to cover the spread in a double-digit win.
Over/Under (?)
Play the OVER 45.5 (-110) with the Niners getting healthier on offense. Both defenses are also riddled by injuries so the Eagles should be able to do enough on the scoreboard.
Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.
Also see:
- Eagles have played fast this season amid calls for the offense to be more uptempo (Eagles Wire)
- Kittle says he’s playing Sunday vs. Eagles (Niners Wire)
Follow @EstenMcLaren on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.
Gannett may earn revenue from audience referrals to betting services. Newsrooms are independent of this relationship and there is no influence on news coverage.
[lawrence-newsletter]
[lawrence-auto-related count=3 category=1367]