The Philadelphia Eagles (4-0) try to maintain their undefeated record on the road Sunday afternoon against the Arizona Cardinals (2-2). Kickoff is 4:25 p.m. ET at State Farm Stadium (FOX). Below, we analyze Tipico Sportsbook‘s lines around the Eagles vs. Cardinals odds, and make our expert NFL picks and predictions.
The Eagles are the only unbeaten team in the league now. They have done it behind a top offense and top defense. They are 4th in the league averaging 28.8 points per game, and defensively, have 16 sacks and 10 takeaways in 4 games.
The Cardinals are 2-0 on the road and 0-2 at home so far this season. They rallied from a 10-3 deficit last week against the Panthers and scored 23 unanswered points in a 26-16 win. QB Kyler Murray threw 2 touchdown passes and rushed for another in the victory.
Also see: All Week 5 odds and lines
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Eagles at Cardinals odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 1:05 p.m. ET.
- Moneyline (ML): Eagles -230 (bet $230 to win $100) | Cardinals +190 (bet $100 to win $190)
- Against the spread (ATS): Eagles -5.5 (-108) | Cardinals +5.5 (-112)
- Over/Under (O/U): 48.5 (O: -112 | U: -108)
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Eagles at Cardinals key injuries
Eagles
- K Jake Elliott (ankle) out
- CB Avonte Maddox (ankle) out
- LT Jordan Mailata (shoulder) doubtful
- RB Boston Scott (rib) questionable
Cardinals
- OL Rodney Hudson (knee) doubtful
- OL D.J. Humphries (hamstring) questionable
- WR RonDale Moore (knee) questionable
- K Matt Prater (hip) out
- OL Justin Pugh (elbow) questionable
- LB Nick Vigil (hamstring) out
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Eagles at Cardinals picks and predictions
Prediction
Eagles 31, Cardinals 27
Moneyline
The Cardinals have lost 7 straight games at home, dating back to last season.
The Eagles, though, have never won in State Farm Stadium and have not beaten the Cardinals in Arizona since 2001.
Murray is 4-0 against former Oklahoma quarterbacks, including 1-0 against Eagles QB Jalen Hurts.
The Eagles’ offense will test the Arizona defense, as they run the ball extremely well, have talented receivers and a quarterback playing at a high level.
Arizona has not scored any 1st-quarter points this season and are the lowest-scoring first-half offense in the league. If the Eagles get a lead, they will be hard to rally against.
But the only reason to bet the moneyline here is if you think the Cardinals can pull the upset. It isn’t worth the action at -230 for the Eagles. PASS.
Against the spread
After a 4th-consecutive slow start for the Cardinals last week, the offense finally got into rhythm in Carolina. They ran the ball for 132 yards and had variety in the passing game. It looked like they finally found themselves, as opposed to the performance Murray put on in Las Vegas to win in Week 2.
If the Cardinals get points early and do not get into a 2-score hole, their defense has been good over the last 10 quarters. They limited Raiders WR Davante Adams to only 2 catches. Rams WR Cooper Kupp had only 4 catches against the Cardinals.
Philly takes the ball away, but the Cardinals protect the football. They have only 2 turnovers this season.
Both teams are fielding replacement kickers as well, so that will be a factor.
I expect a close, competitive game.
Take the CARDINALS +5.5 (-112).
Over/Under
Both of the Eagles’ 1-score games have had 50 total points or more.
Arizona’s offense, if on track like it appeared it was last week in the second half, is capable of putting up 30.
The Eagles have not scored fewer than 24 points this season.
Take OVER 48.5 (-112).
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