Oklahoma at Missouri odds, picks and predictions

Analyzing Saturday’s Oklahoma at Missouri odds and lines, with college football expert picks, predictions and best bets.

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The Oklahoma Sooners (5-4, 1-4 SEC) take on the No. 22 Missouri Tigers (6-2, 2-2) at Memorial Stadium/Faurot Field Saturday. Kickoff is set for 7:45 p.m. ET (SEC Network). Let’s analyze BetMGM Sportsbook’s college football odds around the Oklahoma vs. Missouri odds, and make our expert college football picks and predictions.

The Sooners ended a 3-game losing streak by beating the brakes off Maine in a 59-14 cover as 36.5-point dogs. RB Jovantae Barnes rushed 18 times for 203 yards and 3 TDs. QB Jackson Arnold was 15-for-21 for 224 yards and 2 TDs.

So Oklahoma is taking on the No. 22 team in the country, in its building, and Mizzou is the underdog? What in tarnation?!? Let us explain…

Missouri QB Brady Cook (hand) is doubtful, and backup QB Drew Pyne has been horrendous as Cook has been banged up. Pyne has thrown for 248 yards, 0 TDs and 3 INTs. RB Nate Noel has been out with a foot injury, but is expected to return Saturday. Prized WR Luther Burden III has also been banged up with a shoulder injury and caught 3 balls for 3 yards last week and hasn’t scored a TD since Sept. 21. What was once a season full of college football playoff hopes has begun spiraling down the drain.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Oklahoma at Missouri odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of college football odds. Lines last updated at at 11:30 a.m. ET.

  • Moneyline (ML): Oklahoma -140 (bet $140 to win $100) | Missouri +115 (bet $100 to win $115)
  • Against the spread (ATS): Oklahoma -2.5 (-110) | Missouri +2.5 (-110)
  • Over/Under (O/U): 41.5 (O: -110 | U: -110)

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Oklahoma at Missouri picks and predictions

Prediction

Oklahoma 24, Missouri 10

Moneyline

Two weeks ago, Cook made a miraculous comeback from the hospital to lead Mizzou past Auburn 21-17. Then, he hit his hand on the helmet of a defensive player early in the game against Alabama and was out. The Tigers were caged 34-0 and looked futile with a capital F.

I expect a better showing on offense with a week to prepare behind Pyne, but he has looked awful under center. Oklahoma isn’t the strongest of foes, but it was competitive with Tennessee and beat Auburn a few weeks ago.

I like Oklahoma here, but I’m going with the spread.

PASS.

Against the spread

I like Oklahoma by at least a touchdown here, and this 2.5-point spread is likely to lengthen the closer we get to kickoff.

Take OKLAHOMA -2.5 (-110).

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Over/Under

The Sooners are 4-5 O/U thus far, and Missouri is 2-6. The Tigers’ offense was hit-or-miss even before Cook, Noel and Burden were injured. Without Cook, it has been a joke.

I like the UNDER 41.5 (-110) here.

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