The NFL preseason is in the books and Week 1 of the regular season is soon upon us when the defending champion Los Angeles Rams host the preseason Super Bowl favorite Buffalo Bills on Thursday, Sept. 8.
Other marquee matchups include the Kansas City Chiefs meeting the Arizona Cardinals in a high-level quarterback duel and the Denver Broncos visiting the Seattle Seahawks which will feature 9-time pro bowler QB Russell Wilson under center for the Broncos for the first time as they face his former team. Below, we look at the Week 1 NFL odds and lines; check back for our NFL picks and predictions.
Odds provided by Tipico Sportsbook and last updated Monday, Aug. 29.
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