The Arizona Cardinals and San Francisco 49ers will kick off Sunday afternoon from Levi’s Stadium at 1:05 p.m. Arizona time. The Cardinals are big underdogs.
Who will win?
Cards Wire staff makes their predictions.
Cardinals-49ers Week 5 staff picks and predictions
Jess Root
As much as this could go sideways because the Niners run the ball well and convert on third down regularly. However, after getting embarrassed last week and with a banged-up Niners team, I expect the offense to keep up. It won’t be enough, so I am guessing the Cardinals cover the spread and lose.
49ers 31, Cardinals 27
Howard Balzer
It’s body blow after body blow for the Cardinals. With the expectation that tight end Trey McBride would be active for Sunday’s game, he was then listed as questionable Saturday with an injury to his ribs of unknown severity. Also Saturday, kicker Chad Ryland was elevated from the practice squad, leaving the status of Matt Prater up in the air. While the 49ers have some injury concerns, everything has to go right for the Cardinals to make this a competitive game. They might have to hope the Niners players wilt in the Santa Clara heat.
49ers 28, Cardinals 14
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