New York Giants at Los Angeles Rams odds, picks and best bets

Previewing the New York Giants at Los Angeles Rams Week 4 betting odds, spread and lines, with NFL betting picks, tips and best bets.

The winless New York Giants (0-3) travel across the country for a meeting with the Los Angeles Rams (2-1) on Sunday at 4:05 p.m. ET from SoFi Stadium in Inglewood, Calif. Below, we analyze the Giants-Rams Week 4 matchup, including the betting odds, spread and lines, and look at the best NFL betting options.

Giants at Rams betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 4:18 a.m. ET.

  • Money line: Giants +575 (bet $100, win $575) | Rams -834 (Bet $834, win $100)
  • Against the spread/ATS: Giants +13.5 (-110) | Rams -13.5 (-110)
  • Over/Under: 47.5 (O: -110, U: -110)

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Giants and Rams game notes

  • The Rams beat the Giants 51-17 in their last meeting, Nov. 5, 2017 at East Rutherford, N.J.
  • The Giants rank last in the NFL in rushing, while the Rams are first in rush attempts this season. Giants RB Saquon Barkley is out for the year with a torn ACL.
  • New York is 1-2 against the spread (ATS) this season, with the total going Under in two of its three games. The Rams are 2-1 ATS with a 2-1 Over/Under record.
  • In their last 11 games against the NFC dating back to last season, the Giants are 1-10.
  • The total has gone Over in five of the last six games between the Rams and Giants.

Giants at Rams key injuries

Giants

  • S Jabrill Peppers (ankle) DNP Thursday
  • S Julian Love (knee/ankle) limited Thursday

Rams

  • RB Cam Akers (ribs) DNP Thursday
  • S Jordan Fuller (shoulder) limited Thursday

Giants at Rams: Odds, betting lines, picks and prediction

Prediction

Rams 31, Giants 13

Money line (?)

The Rams are huge favorites over the winless Giants despite suffering a 35-32 loss at the Buffalo Bills in Week 3. The Giants offense is lost without Barkley, and QB Daniel Jones hasn’t proved capable of carrying the load with his star running back out.

At -834, the Rams are a safe bet to win this one, but there’s little reward that comes with betting on them. Still, there’s a very slim chance they’ll lose outright. Take the RAMS (-834).

New to sports betting? Every $834 wagered on the Rams to win outright will return a profit of $100 if they do so.

Against the spread (?)

The Rams are 13.5-point favorites, the second-largest line of Week 4. They’re fully expected to win this game, and after seeing them crush the Philadelphia Eagles in Week 2, there’s no reason to think they can’t win by double-digits.

The Giants have only lost one game by single-digits this season, too, a 17-13 loss to the Chicago Bears. The Rams will win big on Sunday and cover the large spread. Take the RAMS -13.5.

Over/Under (?)

The Over/Under is set at only 47.5 points, which based on how well the Rams offense has been playing implies the oddsmakers don’t expect much help from the Giants.

It’s hard to see how the Giants will move the ball consistently against the Rams, given the way their offense has played. Take the UNDER.

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