New Orleans Saints vs. Arizona Cardinals odds, picks and predictions

Analyzing Thursday’s New Orleans Saints at Arizona Cardinals odds and lines, with expert NFL picks, predictions and best bets.

Week 7 in the NFL kicks off Thursday with the New Orleans Saints (2-4) on the road to face the Arizona Cardinals (2-4). Kickoff is 8:15 p.m. ET at State Farm Stadium in Glendale (Prime Video). Below, we analyze Tipico Sportsbook‘s lines around the Saints vs. Cardinals odds, and make our expert NFL picks and predictions.

The Cardinals are coming off 2 straight losses, failing to score a touchdown offensively in a 19-9 road loss to the Seattle Seahawks as a 2.5-point favorite in Week 6. They sit in last place in the NFC West.

The Saints have lost 4 of their last 5 outings after a season-opening 27-26 victory at the Atlanta Falcons. They 30-26 to the Cincinnati Bengals as 3-point underdogs in Week 6. New Orleans has rushed for over 200 yards in 2 consecutive games.

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Saints at Cardinals odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 5:45 a.m. ET.

  • Moneyline (ML): Saints +115 (bet $100 to win $115) | Cardinals -135 (bet $135 to win $100)
  • Against the spread (ATS): Saints +2.5 (-105) | Cardinals -2.5 (-115)
  • Over/Under (O/U): 44.5 (O: -105 | U: -115)

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Saints at Cardinals key injuries

Saints

  • CB Paulson Adebo (knee) questionable
  • WR Jarvis Landry (ankle) out
  • CB Marshon Lattimore (abdomen) out
  • OL Andrus Peat (chest) out
  • WR Michael Thomas (foot) out
  • TE Adam Trautman (ankle) out

Cardinals

  • WR Marquise Brown (foot) out
  • RB James Conner (ribs) questionable
  • LB Dennis Gardeck (ankle) questionable
  • C Rodney Hudson (knee) out
  • PK Matt Prater (hip) questionable
  • OL Justin Pugh (knee) out
  • Jalen Thompson (hamstring) questionable
  • RB Darrel Williams (knee) out

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Saints at Cardinals picks and predictions

Prediction

Cardinals 23, Saints 20

Moneyline

This will be the first game back for Cardinals WR DeAndre Hopkins, who returns from a 6-game PED suspension. Hopkins will have an opportunity to shine as the Saints are missing their top cornerback.

New Orleans is missing 5 starters to injury Thursday, including 4 on offense.

Arizona’s defense held the high-scoring Philadelphia Eagles and Seahawks to fewer than 20 points each of the last 2 weeks and held the Eagles to their lowest total yardage of any game this season.

The question is whether the Cardinals will be able to get their struggling offense going. They lost Brown to injury but they get back Hopkins and also added WR Robby Anderson via trade with the Carolina Panthers this week.

The Cardinals have lost their last 8 home games dating back to last season. Between the Saints’ injuries and the return of Hopkins, Arizona is due for a home win.

Take the CARDINALS (-135).

Against the spread

The Saints are 2-4 ATS (0-2 ATS on the road) and the Cardinals are 3-3 ATS (1-2 ATS at home).

Both of the Cardinals’ wins this season have been by at least 3 points and 10 of their 11 wins last season were by 3 or more.

Take the CARDINALS -2.5 (-115).

Over/Under

The Under is 5-0 in Arizona’s last 5 games and it has held opponents to 20 or fewer points in 4 straight games. However, the Cardinals have not reached 20 points themselves in 3 of their last 4 contests.

Take UNDER 44.5 (-115).

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