Monday Night Football picks and prop bets: What can Derrick Henry do vs. the Bills?

The Titans routed the Bills at home in 2020. Can they do it again?

The Buffalo Bills are the hottest team in the AFC. Derrick Henry is the hottest running back in the NFL. Can one man’s momentum derail the trajectory of an entire franchise?

That’s what we get to find out Monday night for a showdown with the Tennessee Titans.

Henry has been Tennessee’s workhorse. Through five weeks he’s averaged more than 28 carries per game and is on pace to lead the league in rushing yards and touchdowns for the third straight season. Buffalo has cut a similarly historic path early in the year. It has forced 15 turnovers the last four games — all wins — while scoring at least 35 points in each of those victories.

The Titans will have Julio Jones and potentially A.J. Brown back in the lineup to help Henry strike at the Bills’ explosive defense. Will that be enough for a home upset?

Let’s dig in. All odds via Tipico: