March Madness 2022: Underdog picks for Saturday’s Second Round matchups

Breaking down which underdogs have the best chances to pull off upsets.

The 2022 NCAA Tournament is in full swing and the opening couple of days is already presenting the madness that we crave. Some of the higher-seeded teams are dropping like flies (Colorado State, Iowa, UConn, Kentucky, to name a few) or just narrowly holding on (Arkansas, UCLA, Illinois, Michigan State).

Why would such chaos suddenly end now?

Hate it, or love it, an eight-game Saturday slate is sure to produce plenty of opportunities for the underdogs to come out on top. Here are the few teams who will have the likeliest shots to bust up some brackets.

All odds via Tipico Sportsbook.

[tipico]